Involvement of nuclear and mitochondrial genome on immune function and reproductive performance in dairy cow
Project/Area Number |
26450372
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Animal production science
|
Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 繁殖性 / 免疫機能 / 一塩基多型 / ゲノム / ミトコンドリアDNA / 乳牛 / 免疫細胞機能 / 細菌感染 / ミトコンドリア / 免疫細胞 |
Outline of Final Research Achievements |
Toll-like receptor 4 (TLR4) and TLR2 are receptor for LPS that is released from gram-negative bacteria. In postpartum dairy cows, inflammation diseases such as metritis and mastitis suppress reproductive performance. The present study is to examine the relationships among SNPs for TLR4 and TLR2 and reproductive performance and immune functions. TLR4 SNP affect the production of cytokine, apoptosis and migration of immune cells. In addition, TLR4 SNP affect ovarian function such as ovulation. Moreover, TLR2 SNP influence follicular cell function (steroid production). These data suggest that SNPs for TLR4 and TLR2 are associated with reproductive performance and immune function.
|
Report
(4 results)
Research Products
(10 results)
-
-
-
-
[Journal Article] Long-term impact of puerperal metritis on the profiles of peripheral blood leukocytes in peripartum dairy cows.2016
Author(s)
Magata, F., Kitaoka, R., Morino, I., Teramura, M., Kawashima, C., Haneda, S., Shimizu, T.
-
Journal Title
Anim. Sci. J.
Volume: 87
Issue: 1
Pages: 151-155
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] The effect of single nucleotide polymorphisms in the tumor necrosis factor-a gene on reproductive performance and immune function in dairy cattle.2014
Author(s)
Kawasaki, Y., Aoki, Y., Magata, F., Miyamoto, A., Kawashima, C., Hojo, T., Okuda, K., Shirasuna, K., Shimizu, T.
-
Journal Title
J. Reprod. Dev.
Volume: 60
Pages: 173-178
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Presentation] Effect of endotoxin on ovarian follicle function in domestic animals.2015
Author(s)
Shimizu, T., Horiuchi, M., Miyauchi K., Echizenya, R., Magata, F., Miyamoto, A.
Organizer
International Conference on Biology and Pathology of Reproduction in Domestic Animals
Place of Presentation
Gdansk, Poland
Year and Date
2015-09-26
Related Report
Int'l Joint Research / Invited