Characterization of Angiopoietin like proteins in chicken ovary

• Project/Area Number: 26450373
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Sato Kan 東京農工大学, (連合)農学研究科(研究院), 教授 (20250730)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ニワトリ / 卵生産 / リポタンパク代謝 / ANGPTL-5 / 卵胞発達

Outline of Final Research Achievements

he present study was identified Angiopoietin like proteins (ANGPTLs), which were involved in the follicle development during rapid growth stage of chicken ovarian follicles. ANGPTL5 mRNA expression was high level in the follicles at the rapid growth stage, and the function was clarified to play the role of the inhibitor on lipoprotein lipase activity. The injection of ANGPTL5 protein into laying hens enhanced the uptake of the egg yolk precursor to a follicle. Thus, the present results provide that ANGPTL5 is a novel target for efficient egg production in chickens.

Research Products

• [Journal Article] Cacao bean husk: an applicable bedding material in dairy free-stall barns. (2017)
  • Author(s): Yajima A, Ohwada H, Kobayashi S, Komatsu N, Takehara K, Ito M, Matsuda K, Sato K, Itabashi H, Sugimura S, Kanda S.
  • Journal Title: Asian-Australas J Anim Sci. Volume: 30 Issue: 7 Pages: 1048-1053
  • DOI: 10.5713/ajas.16.0877
  • Peer Reviewed / Open Access
• [Journal Article] Molecular nutrition: Interaction of nutrients, gene regulations and performances. (2016)
  • Author(s): Sato K
  • Journal Title: Animal Science Journal. Volume: 87 Issue: 7 Pages: 857-862
  • DOI: 10.1111/asj.12414
  • Peer Reviewed / Open Access
• [Journal Article] Potential of a smartphone as a stress-free sensor of daily human behaviour. (2015)
  • Author(s): Mimura K, Kishino H, Karino G, Nitta E, Senoo A, Ikegami K, Kunikata T, Yamanouchi H, Nakamura S, Sato K, Koshiba M.
  • Journal Title: Behavioral Brain Research Volume: 1 Pages: 181-189
  • DOI: 10.1016/j.bbr.2014.06.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant