| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
The understanding of the interaction between the early embryos and uterine environment is crucial to reduce the embryonic loss in domestic animals. The present research revealed the mechanisms of action of embryonic and uterine products on bovine uterus during implantations and their interactions.
1) We found that epidermal growth factor (EGF) is mainly produced by uterine luminal cells but not by bovine embryos. 2) EGF protein in bovine endometrium was higher around the time of implantation compared with other luteal stages. 3) Cultured endometrial epithelial cells produce more EGF than endometrial stromal cells. 4) EGF has the ability to increase luteolytic (prostaglandin F2alpha) and luteotropic (prostaglandin E2) in both epithelial and stromal cells. 5) Endometrium contains more EGF around the time of implantation. This growth factor stimulates the production of interferon-tau, the pregnancy recognition factor in cattle, to ensure the establishment of pregnancy.
|
