Improving meat production by fundamental research on myogenic differentiation
| Project/Area Number |
26450391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Kyushu University |
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Principal Investigator |
Nakamura Mako 九州大学, 農学研究院, 准教授 (80452746)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 筋細胞分化 / 食肉科学 / 畜産物 / 活性化衛星細胞 / emerin / Pax7 / Semaphorin 3A / Sema3A / Myf5 / MyoD / semaphorin 3a / differentiation |
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| Outline of Final Research Achievements |
Muscle regeneration is initiated by activation of muscle stem cells, known as satellite cells, which are adjacent to the basal lamina around the proximal region of each myofiber.We previously showed that Semaphorin 3A (Sema3A) expression was induced when quiescent muscle became activated satellite cells (ASCs). However, how Sema3A regulates genes in the early phase of ASCs remains unclear. In this study, we investigated whether Sema3A signaling can regulate the early phase of ASCs. We showed that expression of the myogenic proliferation regulatory factors Pax7 and Myf5 was decreased in myoblasts transfected with Sema3A siRNA. Emerin was also regulated by Sema3A in ASCs.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Transmembrane proteoglycans syndecan-2, 4, receptor candidates for the impact of HGF and FGF2 on semaphorin 3A expression in early-differentiated myoblasts2015
Author(s)
Mai-Khoi Q. Do, Naomi Shimizu, Takahiro Suzuki, Hideaki Ohtsubo, Wataru Mizunoya, Mako Nakamura, Shoko Sawano, Mitsuhiro Furuse, Yoshihide Ikeuchi, Judy E. Anderson, Ryuichi Tatsumi
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Journal Title
Physiological Reports
Volume: 3
Issue: 9
Pages: e12553-e12553
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: Promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle.2014
Author(s)
Sakaguchi S, Shono J, Suzuki T, Shoko S, Anderson JE, Do MKQ, Ohtsubo H, Mizunoya W, Sato Y, Nakamura M, Furuse M, Yamada K, Ikeuchi Y, Tatsumi R.
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Journal Title
International Journal of Biochemistry and Cell Biology
Volume: 52
Pages: 272-285
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Sema3Aはemerin 発現を阻害することで筋特異的因子Pax7およびMyf5 発現を増加させ、筋芽細胞の増殖能を上昇させる2016
Author(s)
Mulann Qahar, Wataru Mizunoya, Ryuichi Tatsumi, Yoshihide Ikeuchi, Mako Nakamura
Organizer
Molecular Mechanisms Modulating Skeletal Muscle Development and Homeostasis in Health and Disease
Place of Presentation
Asilomar Conference Grounds, Pacific Grove （United States of America）
Year and Date
2016-06-09
Related Report
Int'l Joint Research
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[Presentation] Anti-inflammatory macrophages implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., Ikeuchi, Y., and Tatsumi, R. (*equal contributors)
Organizer
Animal Science Congress 2014 of the Asian-Australian Association of Animal Production Societies
Place of Presentation
Universitas Gadjah Mada (UGM),Indonesia
Year and Date
2014-11-10 – 2014-11-14
Related Report
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[Presentation] Functional interaction between Sema3A and Pax7 in proliferation and differentiation of myoblasts.2014
Author(s)
Mulan, Nakamura, M., Suzuki, T., Mizunoya, W., Ojima, K., Tatsumi, R. and Ikeuchi, Y.
Organizer
International Symposium on Agriculture, Forestry, Environment and Life Sciences in Asia, 2014 (AFELiSA'14)
Place of Presentation
Ladena Condominium, Korea
Year and Date
2014-10-28 – 2014-10-31
Related Report
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[Presentation] M2 macrophages may implicate in regenerative moto-neuritogenesis, by promoting myoblast migration and Sema3A expression.2014
Author(s)
Tatsumi, R.,* Sakaguchi, S.,* Shono, J.,* Suzuki, T.,* Sawano, S., Anderson, J.E., Do, M.-K.Q., Ohtsubo, H., Mizunoya, W., Nakamura, M., Furuse, M., and Ikeuchi, Y. (*equal contributors)
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] APOBEC2 deficiency up-regulates myoblast differentiation.2014
Author(s)
Ohtsubo, H., Sato, Y., Suzuki, T., Mizunoya, W., Nakamura, M., Tatsumi, R., and Ikeuchi, Y.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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[Presentation] Sema3A secreted from satellite cells promotes slow-twitch fiber generation.2014
Author(s)
Suzuki, T., Ohya, Y., Ojima, K., Mizunoya, W., Sawano, S., Ohtsubo, H., Nishimatsu, S., Anderson, J. E., Do, M.-K. Q., Nakamura, M., Furuse, M., Ikeuchi, Y., Nohno, T., and Tatsumi, R.
Organizer
2014 FASEB Science Research Conference on “Skeletal Muscle Satellite and Stem Cells”
Place of Presentation
Steamboat Springs, CO, USA
Year and Date
2014-07-20 – 2014-07-25
Related Report
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