| Project/Area Number |
26450404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
MURANO Takako
KITAMURA Yuko
TANAKA Ai
ISHIHARA Tsugumi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ワクモ / 制御 / 薬剤抵抗性 / ワクチン / 鶏病 / ニワトリ / 薬剤 / 外部寄生虫 |
|---|
| Outline of Final Research Achievements |
The chicken red mite is known as one of the most problematic blood-sucking ectoparasite in poultry industry. Usually, acaricides are mainly used for prevention of the mite. However, acaricide resistant mites has been emerged worldwide, and development of another effective control procedure for the mite is expected. In the present study, to dissolve the problem, molecular mechanism of drug resistance of the mite was studied and vaccine candidate molecule against the mite were investigated. The nucleotide sequences of the entire coding regions corresponding to the target molecules of each acaricide were determined, and amino acid substitutions involved in the resistance were revealed. Furthermore, transcriptome analysis of all stages of the mite performed with next-generation sequencing revealed nucleotide sequences of transcripts which code vaccine candidate molecules.
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