Roles of MARCKS in platelets, smooth muscle and endothelial cells in haemostasis and thrombosis
| Project/Area Number |
26450407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
SHIRAISHI Mitsuya 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (20383656)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMOTO Atsushi 鹿児島大学, 農水産獣医学域獣医学系, 教授 (70219806)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MARCKS / 血管内皮細胞 / 血管平滑筋細胞 / 血小板 / 血管平滑筋 / カルパイン / メチル水銀 |
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| Outline of Final Research Achievements |
We studied the role of MARCKS protein in endothelial cells, smooth muscle cells, and platelets. In endothelial cells, MARCKS protein was involved in cell proliferation, cell migration, and nitric oxide production. Furthermore, participation of MARCKS in abnormal cell functions of diabetes or methylmercury intoxication model animals was suggested. In addition, MARCKS was expressed in smooth muscle cells and platelets, and the role of MARCKS in these cells was indicated.
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Report
(5 results)
Research Products
(18 results)
