Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
We evaluated SNPs on ALK3 and ALK7 genes using a total of 55 dogs of various breeds, which have been shown to relate to obesity in humans; no SNPs were detected. Treatment with TGF-β1, activin A, activin B, BMP4 or BMP7 increased expression level of adipose triglyceride lipase. TGF-β family affected cellular content of free amino acids in adipocytes. Especially, insulin-induced decrease in cellular content of arginine, glutamic acid and phenylalanine was exaggerated by TGF-β1, activin A and activin B.
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