Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
EW135 is a chicken egg white protein with 9 tandem repeats of group B scavenger receptor cysteine rich (SRCR) domain. We previously discovered a chicken serum protein named CS120 which reacts with anti-EW135 antibodies. The purpose of this project was to elucidate the structure and function of CS120. We developed a method for the purification of CS120 by using ion-exchange and affinity chromatographies. By cDNA cloning, the primary structure of CS120 has been determined. CS120 was found to consist of 8 tandem repeats of group B SRCR domain. CS120 bound to Staphylococcus aureus and protein A, while it did not show an anti-influenza virus activity.
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