| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Adenovirus vectors are widely used in cancer gene therapies, and be expected to be effective also in gene therapy in veterinary medicine. However, there is a problem that adenovirus vectors induce innate immune responses more than necessary, such as inducing high production of inflammatory cytokines after administration. It has been suggested that glycosphingolipids on the cell membrane regulate TLR signals, but it has not been cleared whether or not these glycosphingolipids are involved in activation of innate immune response by adenoviral vector administration. In this study, we examined the involvement of glycosphingolipids in activation of innate immune response by adenoviral vector administration.
|
