The regulatory mechanism of sperm motility using long-chain fatty acids as signal molecules
| Project/Area Number |
26450452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | FFAR4 / GPR120 / 長鎖脂肪酸 / 精子 / 運動性 / Akt / p38 / 脂肪酸 / 不飽和脂肪酸 |
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| Outline of Final Research Achievements |
In the present study, activation of GPR120 induced increase in sperm motility via PI3K/Akt and p38 MAPK pathway. This evidence suggests that extracellular LCFAs act as signal molecles that regulate sperm motility through FFAR4.
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Report
(4 results)
Research Products
(12 results)
