The regulatory mechanism of sperm motility using long-chain fatty acids as signal molecules

• Project/Area Number: 26450452
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Kindai University
• Principal Investigator: MORIYAMA Ryutaro 近畿大学, 理工学部, 講師 (30411573)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: FFAR4 / GPR120 / 長鎖脂肪酸 / 精子 / 運動性 / Akt / p38 / 脂肪酸 / 不飽和脂肪酸

Outline of Final Research Achievements

In the present study, activation of GPR120 induced increase in sperm motility via PI3K/Akt and p38 MAPK pathway. This evidence suggests that extracellular LCFAs act as signal molecles that regulate sperm motility through FFAR4.

Research Products

• [Journal Article] Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene (2016)
  • Author(s): Moriyama R, Yamazaki T, Kato T, Kato Y
  • Journal Title: Journal of Reproduction and Development Volume: 62 Issue: 2 Pages: 195-199
  • DOI: 10.1262/jrd.2015-138
  • NAID: 130005146470
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland. (2015)
  • Author(s): R. Moriyama, C. Deura, S. Imoto, K. Nose and N. Fukushima
  • Journal Title: Histochemistry and Cell Biology Volume: 143(1) Issue: 1 Pages: 21-27
  • DOI: 10.1007/s00418-014-1257-3
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Activation of FFAR4 improves sperm motility through the PI3K/Akt and p38 MAPK pathway (2017)
  • Author(s): Ryutaro Moriyama, Chiaki Umeda, Yume Yamamoto, Ikumi Wakasa.
  • Organizer: 4th World Congress of Reproductive Bilogy (WCRB2017)
  • Place of Presentation: Okinawa Convention Center, Okinawa
  • Year and Date: 2017-09-27
  • Int'l Joint Research
• [Presentation] マウス下垂体のゴナドトロフに局在する長鎖脂肪酸受容体GPR120発現におけるエストロジェンとプロジェステロンの役割 (2016)
  • Author(s): 上田佳穂、十河由紀、森山隆太郎
  • Organizer: 第109回 日本繁殖生物学会大会
  • Place of Presentation: 麻布大学, 相模原市
  • Year and Date: 2016-09-11
• [Presentation] Effect of estrogen and progesterone on the expression of long-chain fatty acid receptor GPR120 in mouse gonadotrophs. (2016)
  • Author(s): Ryutaro Moriyama, Yuki Sogo, Kaho Ueda
  • Organizer: International Symposium on Pituitary Gland and Related Systems (ISPGR2016)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2016-09-01
  • Int'l Joint Research
• [Presentation] ゴナドトロフにおけるリゾホスファチジン酸(LPA)の役割の検討 (2015)
  • Author(s): 森山隆太郎、田近弘樹
  • Organizer: 第108回 日本繁殖生物学会大会
  • Place of Presentation: 宮崎大学, 宮崎
  • Year and Date: 2015-09-17
• [Presentation] AMPK経路を介したLH beta鎖発現抑制 (2015)
  • Author(s): 森山隆太郎、山崎翼、加藤たか子、加藤幸雄
  • Organizer: 第30回 下垂体研究会学術集会
  • Place of Presentation: 宇奈月国際会館セレネ, 富山
  • Year and Date: 2015-08-05
• [Presentation] Long-chain fatty acid exposure regulates mouse sperm motility. (2014)
  • Author(s): R. Moriyama, I. Wakasa, M. Nakagawa
  • Organizer: World Congress of Reproductive Biology 2014
  • Place of Presentation: Edinburgh International Conference Centre, Scotland
  • Year and Date: 2014-09-02 – 2014-09-04
• [Presentation] グルコース利用性の低下が下垂体の性腺刺激ホルモン遺伝子の転写調節に与える影響 (2014)
  • Author(s): 森山隆太郎、山崎翼、中井愛、加藤たか子、加藤幸雄
  • Organizer: 第107回日本繁殖生物学会大会
  • Place of Presentation: 帯広畜産大学、北海道
  • Year and Date: 2014-08-20 – 2014-08-23
• [Presentation] 性腺刺激ホルモン発現における長鎖脂肪酸の役割 (2014)
  • Author(s): 森山隆太郎、山崎翼、加藤たか子、加藤幸雄
  • Organizer: 第29回下垂体研究会学術集会
  • Place of Presentation: 八王子セミナーハウス、東京都
  • Year and Date: 2014-08-08 – 2014-08-10
• [Remarks] 近畿大学 理工学部 生命科学科 環境生理学研究室HP
  • URL: http://www.life.kindai.ac.jp/~mory/MNB2/index.html
• [Remarks] 近畿大学 理工学部 生命科学科 環境生理学研究室のHP
  • URL: http://www.life.kindai.ac.jp/~mory/index.html