| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The purpose of this study is to understand motion patterns and regulatory mechanisms of stem and differentiating cells in mouse seprmatogenesis. In this study, we found that stem cells move actively and randomly, while differentiating cells are less motile. We also found that heterogeneous motion is likely to be generated by two mechanisms: syncytial formation (unique biological event in spermatogenesis) and cell state-dependent motion property. Future analysis for molecular mechanisms of stem/differentiating cell motion and biological significance of stem cell motion will be needed. During this support, we published a paper in Cell Stem Cell (Hara etal., 2014).
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