Elucidation of patterns and regulatory mechanism of undifferentiated spermatogonial motion in mouse testis
| Project/Area Number |
26450453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Tohoku University (2015-2016)
National Institute for Basic Biology (2014) |
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Principal Investigator |
Hara Kenshiro 東北大学, 農学研究科, 准教授 (60551546)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Shosei 自然科学研究機構, 基礎生物学研究所, 教授 (60294138)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精巣 / 精子幹細胞 / 精原細胞 / 細胞運動 / 精子形成 |
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| Outline of Final Research Achievements |
The purpose of this study is to understand motion patterns and regulatory mechanisms of stem and differentiating cells in mouse seprmatogenesis. In this study, we found that stem cells move actively and randomly, while differentiating cells are less motile. We also found that heterogeneous motion is likely to be generated by two mechanisms: syncytial formation (unique biological event in spermatogenesis) and cell state-dependent motion property. Future analysis for molecular mechanisms of stem/differentiating cell motion and biological significance of stem cell motion will be needed. During this support, we published a paper in Cell Stem Cell (Hara etal., 2014).
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.2017
Author(s)
Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
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Journal Title
Stem Cell Reports.
Volume: 8
Issue: 3
Pages: 561-575
DOI
NAID
Related Report
Peer Reviewed / Open Access
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