Mechanism of reproductive physiology under the condition of fasting and low metabolism - Hibernating bears as a model -

• Project/Area Number: 26450455
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Hokkaido University
• Principal Investigator: Tsubota Toshio 北海道大学, 獣医学研究科, 教授 (10207441)
• Co-Investigator(Kenkyū-buntansha): 佐鹿 万里子 北海道大学, 獣医学研究科, 助教 (30722954) ; 下鶴 倫人 北海道大学, 獣医学研究科, 准教授 (50507168)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ツキノワグマ / 冬眠 / 心拍数 / 体温 / 妊娠 / 擬妊娠 / ロガー / 肥満 / 脂肪 / アディポネクチン / クマ / 低代謝状態 / 繁殖 / 出産 / 哺育 / 体脂肪

Outline of Final Research Achievements

Heart rate (HR) and subcutaneous body temperature (BT) were being monitored by using data loggers (DST milli-HRT, Star:Oddi) for the measurement of HR and BT, which were implanted at the breast region, for about 6 months during winter season including pre-hibernation, hibernation and post-hibernation periods. In January, pregnancy diagnosis was done by using ultrasonography for these 5 bears. Notable findings were relationships between HR and BT in pregnant bears: both HR and BT during pre-hibernation period (delayed implantation period) changed with about 24 hours cycle, BT maintained relatively high and HR exhibited some spike during hibernation period (fetal development period) and both synchronized fluctuation with multi-day cycles during post-hibernation period (natal development period).

Research Products

• [Presentation] 飼育下ツキノワグマにおける冬眠前および冬眠中の体温および心拍数の変化 (2016)
  • Author(s): 坪田敏男，鈴木信吾，宮城太輔，山﨑晃司，佐鹿万里子，下鶴倫人
  • Organizer: 第22回日本野生動物医学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎市）
  • Year and Date: 2016-09-16
• [Presentation] Changes in body temperature and heart rate related with hibernation in captive Japanese black bears (Ursus thibetanus japonicus) (2016)
  • Author(s): Toshio TSUBOTA, Shingo SUZUKI, Daisuke MIYAGI, Koji YAMAZAKI, Mariko SASHIKA and Michito SHIMOZURU
  • Organizer: The 24th International Conference on Bear Research and Management
  • Place of Presentation: アンカレッジ，アメリカ合衆国
  • Year and Date: 2016-06-13
  • Int'l Joint Research
• [Presentation] ツキノワグマにおける冬眠期の皮下体温、腹腔内体温および活動量測定の試み (2015)
  • Author(s): 鈴木信吾、山崎晃司、佐鹿万里子、下鶴倫人
  • Organizer: 第158回日本獣医学会学術集会
  • Place of Presentation: 北里大学（十和田）
  • Year and Date: 2015-09-07
• [Presentation] ヒグマの冬眠の話 (2015)
  • Author(s): 下鶴倫人
  • Organizer: CISEネット・サイエンステーリング円山動物園
  • Place of Presentation: 札幌市円山動物園
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] ヒグマの冬眠の話 (2014)
  • Author(s): 坪田敏男
  • Organizer: CISEネット・サイエンステーリング円山動物園
  • Place of Presentation: 札幌市円山動物園
  • Year and Date: 2014-10-18
  • Invited
• [Presentation] 野生動物医学からクマへのアプローチ～飼育下実験、死体分析およびフィールドワーク～ (2014)
  • Author(s): 坪田敏男
  • Organizer: 第20回日本野生動物医学大会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2014-09-16 – 2014-09-19
  • Invited
• [Book] ホルモンから見た生命現象と進化 (2016)
  • Author(s): 坪田敏男
  • Total Pages: 180
  • Publisher: 裳華房
• [Book] ホルモンから見た生命現象と進化 第６巻回遊・渡りー巡ー (2016)
  • Author(s): 坪田敏男
  • Total Pages: 180
  • Publisher: 裳華房
• [Remarks] 野生動物学教室
  • URL: http://wildlife.vetmed.hokudai.ac.jp/