| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Since transcription factor DAF-16 is required for lifespan extension in various long-lived mutants of the nematode C. elegans, it has been considered as a longevity gene. However, these results are based on genetic analysis and it is unclear whether transcriptional activity of DAF-16 is actually increased in long-lived mutants. Here we established novel in vivo luc system in C. elegans and demonstrated that there is a positive correlation between lifespan extension and DAF-16 activity.
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