| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The hydroacylation of 4-allenal proceeded smoothly, giving 6-membered ketones in good yields (up to 84% yield) with high ee’s (up to 96% ee) even though racemic allenes were used as substrates. The mechanistic studies revealed that the nitrile would accelerate the racemization of allene rather than improve the yield and ee of the product. Additionally, I have succeeded in development of several new cyclizations using allene as a substrate. In these reactions, it was found that the racemization of allene moiety would be easy to occur under reaction conditions.
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