Development of novel cyclization reactions via formation of ruthenacycle intermediate and their application to organic synthesis
| Project/Area Number |
26460002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University (2015-2016)
Hokkaido University (2014) |
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Principal Investigator |
Saito Nozomi 明治薬科大学, 薬学部, 教授 (80349258)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 環化反応 / ルテニウム / メタラサイクル / アレン / アルキン / 環状化合物 / 天然物合成 / アルカロイド / ルテナサイクル / ルテニウムカルベン / 配位子 |
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| Outline of Final Research Achievements |
Studies on the development of the novel cyclization reactions via ruthenacyclopentene intermediate formed by oxidative cyclization of allene and alkyne were conducted. Furthermore, we performed synthetic studies on indole alkaloids by using the above our ruthenium-catalyzed cyclization as a key step.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Self-assembled Multi-layer Stabilized Nickel Nanoparticle Catalyst for Ligand-free Cross-coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
Author(s)
Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
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Journal Title
Adv. Synth. Catal.
Volume: 358
Issue: 15
Pages: 2449-2459
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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