| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Based on the convergent synthetic strategy for CJ-12,950, we realized the total synthesis of a possible diastereomer of CJ-12,950. Sharpless asymmetric epoxidation and Keck asymmetric allylation were utilized for the construction of the key chiral centers on the macrolactone. Furthermore, we found that the Zhan-1b catalyst works much better than the Grubbs or Hoveyda-Grubbs catalyst for the ring closing metathesis and [Cp*RhCl2]2-mediated coupling reaction of O-pivaloyl hydroxamic acid with pinacol vinylboronate was critical for the pendant amide formation.
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