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Syntheses of Cationic Metal Complexes with Z-Ligand and Its Application

Research Project

Project/Area Number 26460004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionKanazawa University

Principal Investigator

Inagaki Fuyuhiko  金沢大学, 薬学系, 准教授 (80506816)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsZ型配位子 / 金 / 触媒反応 / 環化反応 / 金属活性化
Outline of Final Research Achievements

The Au complexes featuring a Z-type ligand (boron atom) as a σ-acceptor were developed for elucidating the effect of electron withdrawing on catalytic reactions. An cyclization in the presence of either [Au→B]+ or [Au]+ showed that [Au→B]+ promotes the reactivity, which enabled the effective construction of not only five- and six-membered rings, but also seven-membered rings.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 5 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] CO2-Selective Absorbents in Air: Reverse Lipid Bilayer Structure Forming Neutral Carbamic Acid in Water without Hydration2017

    • Author(s)
      Inagaki, F.; Matsumoto, C.; Iwata, T.; Mukai, C.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 139 Issue: 13 Pages: 4639-4642

    • DOI

      10.1021/jacs.7b01049

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Some Benzimidazole Derivatives Endowed with 1,2,3-Triazole as Potential Inhibitors of Hepatitis C Virus2016

    • Author(s)
      Youssif, B. G. M.; Mohamed, Y. A. M.; Salim, M. T. A.; Inagaki, F.; Mukai, C.; Abdu-Allah, H. H. M.
    • Journal Title

      Acta Pharm.

      Volume: 66 Issue: 2 Pages: 219-231

    • DOI

      10.1515/acph-2016-0014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Energyless CO<sub>2</sub> Absorption, Generation, and Fixation Using Atmospheric CO<sub>2</sub>2016

    • Author(s)
      F. Inagaki, Y. Okada, C. Matsumoto, M. Yamada, K. Nakazawa, C. Mukai
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 1 Pages: 8-13

    • DOI

      10.1248/cpb.c15-00793

    • NAID

      130005115806

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Concise Construction of Bicyclo[6.4.0] and -[7.4.0] Frameworks by [4+2] Cycloaddition of 3,4-Dimethylene-2,5-bis(phenylsulfonyl)cycloalk-1-enes2015

    • Author(s)
      C. Mukai, M. Ueda, Y. Takahashi, F. Inagaki
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 2015 Issue: 20 Pages: 4412-4422

    • DOI

      10.1002/ejoc.201500598

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rhodium(I)-Catalyzed Cycloisomerization of Allene-Allenylcyclopropanes2015

    • Author(s)
      T. Kawamura, Y. Kawaguchi, K. Sugikubo, F. Inagaki, C. Mukai.
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 2015 Issue: 4 Pages: 719-722

    • DOI

      10.1002/ejoc.201403535

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Air-Stable Cationic Gold(I) Catalyst Featureing a Z-Type Ligand: Promoting Enyne Cyclization2015

    • Author(s)
      F. Ingaki, C. Matsumoto, Y. Okada, N. Maruyama, C. Mukai
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 54 Issue: 3 Pages: 818-822

    • DOI

      10.1002/anie.201408037

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Propargyltrimethylsilanes as Allene Equivalents in Transition Metal Catalyzed [5+2] Cycloadditions2014

    • Author(s)
      P. A. Wender, F. Inagaki, M. Pfaffenbach, M. C. Stevens
    • Journal Title

      Org. Lett.

      Volume: 16 Issue: 11 Pages: 2923-2925

    • DOI

      10.1021/ol501114q

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural Complexity Through Multicomponent Cycloaddition Cascades Enabled by Dual-Purpose, Reactivity Regenerating 1,2,3-Triene Equivalents2014

    • Author(s)
      P. A. Wender, D. N. Fournogerakis, M. S. Jeffreys, R. V. Quiroz, F. Inagaki, M. Pfaffenbach
    • Journal Title

      Nature Chem.

      Volume: 6 Issue: 5 Pages: 448-452

    • DOI

      10.1038/nchem.1917

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 銀触媒を用いたアリルスルホンアミドの選択的脱アリル化反応の開発2017

    • Author(s)
      稲垣 冬彦, 平 至仙, 向 智里
    • Organizer
      日本薬学会 第137年会(仙台)
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジヒドロアスパラガス酸及びその誘導体の合成と各種ジチオールを用いたタンパク質の還元2017

    • Author(s)
      稲垣 冬彦, 百瀬 幸, 丸山 直哉, 向 智里
    • Organizer
      日本薬学会 第137年会(仙台)
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Z型配位子を持つ金錯体の設計とその触媒反応2017

    • Author(s)
      稲垣 冬彦
    • Organizer
      日本薬学会 第137年会(仙台) 一般シンポジウムS56 精密制御反応場が拓く有機合成化学の最前線
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 2-OXAZOLIDINONE SYNTHESIS: METAL-CATALYZED CARBOXYLATION USING ATMOSPHERIC CO2 AT AMBIENT TEMPERATURE2016

    • Author(s)
      Fuyuhiko Inagaki, Yasuhiko Okada, Chiaki Matsumoto, Masayuki Yamada, Kenta Nakazawa, Chisato Mukai
    • Organizer
      The 27th European Colloquium on Heterocyclic Chemistry (ECHC2016)
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物合成を志向した簡便なビシクロ[6.4.0]及び[7.4.0]骨格構築法の開発2015

    • Author(s)
      向 智里、上田将信、高橋康仁、稲垣冬彦
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      早稲田大学 東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Z型配位子含有カチオン性金錯体の合成とその環化反応への応用2015

    • Author(s)
      稲垣冬彦, 松本千明, 岡田泰彦, 丸山直哉, 向 智里
    • Organizer
      第41回 反応と合成の進歩シンポジウム
    • Place of Presentation
      近畿大学 大阪
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Air-Stable Cationic Gold(I) Catalyst Featuring Z-Type Ligand and Its Promoting Activity of Enyne Cyclizations2015

    • Author(s)
      Fuyuhiko Inagaki, Chiaki Matsumoto, Yasuhiko Okada, Naoya Maruyama, Chisato Mukai
    • Organizer
      The 18th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 18)
    • Place of Presentation
      Sitges Barcelona Spain
    • Year and Date
      2015-06-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Z型配位子による金触媒反応の活性化2015

    • Author(s)
      稲垣冬彦、松本千明、岡田泰彦、丸山直哉、向智里
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸学院大学、兵庫医療大学(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ビシクロ[m.4.0]骨格(m=6, 7)の効率的構築法の開発2015

    • Author(s)
      向智里、上田将信、高橋康仁、稲垣冬彦
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸学院大学、兵庫医療大学(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Diels- Alder反応を用いた新規ビシクロ[m.4.0]骨格(m = 6, 7)の効率的構築法の開発2014

    • Author(s)
      向智里、上田将信、高橋康仁、稲垣冬彦
    • Organizer
      日本薬学会 北陸支部 第126回例会
    • Place of Presentation
      金沢大学(金沢)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] A progress in carbonylative [2+2+1] cycloaddition: First utilization of nitrile group as π- component2014

    • Author(s)
      岩田隆、稲垣冬彦、向智里
    • Organizer
      15 th Tetrahedron Symposium Asia Edition
    • Place of Presentation
      シンガポールExpo(シンガポール)
    • Year and Date
      2014-10-28 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] RhI- Catalyzed Csp3- Csp3 Bond Activation of Cycloalkanes2014

    • Author(s)
      Chisato Mukai, Yasuaki Kawaguchi, Yuu Ohta, Katsuya Sugikubo, Yuki Oura, Yusuke Miyashita, Fuyuhiko Inagaki
    • Organizer
      Conference on C-C Bond Cleavage
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2014-10-24 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 空気由来の二酸化炭素の吸収剤及び発生剤2016

    • Inventor(s)
      稲垣冬彦,向智里,岡田泰彦,松本千明 山田将之,中澤研太
    • Industrial Property Rights Holder
      稲垣冬彦,向智里,岡田泰彦,松本千明 山田将之,中澤研太
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2017-031046
    • Filing Date
      2016-07-27
    • Acquisition Date
      2017-02-09
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 2-オキサゾリジノン誘導体の製造方法2015

    • Inventor(s)
      稲垣冬彦,向智里,岡田泰彦,松本千明 山田将之,中澤研太
    • Industrial Property Rights Holder
      稲垣冬彦,向智里,岡田泰彦,松本千明 山田将之,中澤研太
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2017-031062
    • Filing Date
      2015-07-29
    • Acquisition Date
      2017-02-09
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 2-オキサゾリジノン誘導体の製造方法2015

    • Inventor(s)
      稲垣冬彦、向智里、岡田泰彦、松本千明、山田将之、中澤研太
    • Industrial Property Rights Holder
      稲垣冬彦、向智里、岡田泰彦、松本千明、山田将之、中澤研太
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-29
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 空気由来の二酸化炭素の吸収剤及び発生剤2015

    • Inventor(s)
      稲垣冬彦、向智里、岡田泰彦、松本千明、山田将之、中澤研太
    • Industrial Property Rights Holder
      稲垣冬彦、向智里、岡田泰彦、松本千明、山田将之、中澤研太
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-29
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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