Direct intra- and intermolecular aldol reactions by catalytic discrimination of aldehydes
Project/Area Number |
26460007
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Kyoto University |
Principal Investigator |
Furuta Takumi 京都大学, 化学研究所, 准教授 (30336656)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 交差アルドール反応 / 位置選択性 / 立体選択性 / 不斉触媒 / アニリン / 軸性不斉 / 酸塩基触媒 / アニリン型アミノ基 / 位置選択的反応 / 立体選択的反応 / 含窒素複素環 |
Outline of Final Research Achievements |
Catalytic discrimination among similarly reactive functional groups is a key to realizing unique and efficient chemo- and regioselective transformations of multi-functionalized molecules; however, formidable challenges to such discrimination remain. Upon developing axially chiral aniline-type acid base catlysts, catalytic discrimination among formyl groups bearing similar reactivity was achieved in the highly regio-, diastereo-, and enantioselective intramolecular cross-aldol reactions of enolizable aliphatic dials.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Enantioselective Synthesis of SB-2032072014
Author(s)
Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama and Toshiyuki Kan
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Journal Title
Org. Lett.
Volume: 16
Issue: 6
Pages: 1646-1646
DOI
Related Report
Peer Reviewed
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