Development of novel synthetic methods of nitrogen-containing compounds based on ene-type reactions of enamines and aza-enamines
| Project/Area Number |
26460010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Sugiura Masaharu 熊本大学, 大学院生命科学研究部(薬), 准教授 (00376592)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エン型反応 / エナミン / 含窒素化合物 / 立体選択的合成法 / 反応開発 / アザアリルアニオン / トリクロロシラン / ワンポット反応 / ワンポット合成 |
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| Outline of Final Research Achievements |
Enamines undergo ene-type reactions with N-sulfonylimines or a N-sulfonylisocyanate as electrophiles. Subsequent reduction with sodium cyanoborohydride affords N-sulfonyl-1,3-dimamines or 3-aminoamides stereoselectively. Overall stereochemistry differs from that of domino reaction between enamines, electrophiles, and trichlorosilane.
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Report
(4 results)
Research Products
(27 results)
