Synthetic study of habiterpenol
Project/Area Number |
26460013
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
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Research Institution | Kitasato University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 全合成 / 構造活性相関 / 創薬研究 / 合成化学 / 創薬化学 |
Outline of Final Research Achievements |
Habiterpenol (1) was isolated from the fermentation broth of actinomycete Phytohabitans suffuscus 3787_5. Habiterpenol was found to abrogate bleomycin-induced G2 arrest in Jurkat cells. Due to its intriguing structural features and biological profile, total synthesis and structure-activity relationship study of this natural product were investigated. As a result, we successfully synthesized a key intermediate for the total synthesis.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.2015
Author(s)
Yamamuro, D.; Uchida, R.; Ohtawa, M.; Arima, S.; Futamura, Y.; Katane, M.; Homma, H.; Nagamitsu, T.; Osada, H.; Tomoda, H.
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Journal Title
Bioorganic & Medicinal Chemistry Letters
Volume: 25
Pages: 313-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Design, synthesis, and biological evaluation of air-stable nafuredin-γ analogs as complex I inhibitors.2015
Author(s)
Ohtawa, M.; Matsunaga, M.; Fukunaga, K.; Shimizu, R.; Shimizu, E.; Arima, S.; Ohmori, J.; Kita, K.; Shiomi, K.; Omura, S.; Nagamitsu, T.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume: 23
Pages: 932-943
DOI
Related Report
Peer Reviewed
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