| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Synthetic study of tricyclic diterpenoid curcusones possess antitumor activity were demonstrated. For the reason that the polycyclic acetal compound was obtained instead of the desired product at the synthetic study of key intermediate lactone, the ring expansion reaction was performed as a new synthetic pathway to construct a seven-membered ring. Furthermore, the construction of the tricyclic skeleton of target natural compound curcusones was accomplished with several procedures including Mukaiyama aldol reaction.
On the other hand, construction of polyoxygenated framework of afritoxinone A and efficient asymmetric total synthesis of catunaregin were achieved based on the side reaction at the synthetic study of lactone moiety.
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