Synthetic Study of Antimitotic Glycolipid Nigricanoside
| Project/Area Number |
26460017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ニグリカノシド / 糖脂質 / エーテル合成 |
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| Outline of Final Research Achievements |
Nigricanosides, isolated from green alga, are unique structural glycolipids. Nigricanosides contain the same components as the monogalactosyldiacylglycerols, the ether linkages connecting the lipids to each other and to the galactose residue are without precedent. Nigricanoside A dimethyl ester display strong antitumor activity. The seven asymmetric centers of nigricanoside except galactose residue are not determined.
Synthesis of dihydroxytetrahydrofuran derivative from diepoxyester was successfully carried out by hydrolysis of ester and then treatment with TsOH. A compound equivalent to the fatty acid dimer residue of nigricanoside would be synthesized if C-C bond at C11-C10’ of dihydroxytetrahydrofuran derivative would be cleavage.
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Report
(4 results)
Research Products
(1 results)
