Synthetic study of ent-kaurene diterpenoids based on tandem cyclization reaction
Project/Area Number |
26460018
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 有機化学 / 合成化学 / 天然物合成 / ラジカル反応 / 連続反応 / カウレン類 / Diels-Alder反応 |
Outline of Final Research Achievements |
Ent-kaurenes diterpenoids, isolated from isodon herbs such as Rabdosia japonica, are known to have useful biological activities. In this study, we focus on the total synthesis of ent-kauren-15-ones showing NF-κB inhibitory activity. A tandem cyclization reaction was designed as an efficient method for construction of the kaurene skeleton composed of 6/6/6/5 membered rings including bicyclo [3.2.1] octane. As a result of various synthetic investigations, we have found a method based on an intramolecular tandem radical cyclization reaction using low valence titanium ion.
|
Report
(4 results)
Research Products
(5 results)