| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Intramolecular chirality transfer reaction is one of useful reactions for synthesizing chiral cyclic compounds. Although the Bi(OTf)3 have been reported to be effective catalyst for the synthesis of 1-substituted tetrahydrioquinolines from chiral amino allylic alcohols, there are some limitations such as failure to synthesize 8-substituted derivatives with high optical purity. In this research, HClO4 found to be most effective catalyst replacing Bi(OTf)3. Furthermore, formal synthesis of alkaloid, Schultzain B, has been accomplished through the construction of a tetrahydroisoquinoline ring having substituents at the 6th and 8th positions.
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