Domino bond-forming reactions by conjugate addition to unsaturated carbonyl compounds and the following redox reactions
| Project/Area Number |
26460021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 連続反応 / 多結合一挙形成 / 酸化 / 還元 |
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| Outline of Final Research Achievements |
Asymmetric conjugate addition of N-allyl lithium amide to α,β-unsaturated esters and the following cyclization reaction was examined. Conversion of intermediate lithium enolate to zinc enolate was effective to react with intramolecular olefin, and the cyclized product was obtained in a one pot with high enantio- and diastereoselectivity in high yield. We also found strong organobase-catalyzed intramolecular hydroamination reaction of aminoalkenes.
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Report
(4 results)
Research Products
(11 results)
