| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Asymmetric conjugate addition of N-allyl lithium amide to α,β-unsaturated esters and the following cyclization reaction was examined. Conversion of intermediate lithium enolate to zinc enolate was effective to react with intramolecular olefin, and the cyclized product was obtained in a one pot with high enantio- and diastereoselectivity in high yield. We also found strong organobase-catalyzed intramolecular hydroamination reaction of aminoalkenes.
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