Investigation of tandem reaction using advantage of the substitution effect of the unsaturated bond
| Project/Area Number |
26460025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
Yanada Reiko 広島国際大学, 薬学部, 教授 (80239821)
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| Co-Investigator(Kenkyū-buntansha) |
岡本 典子 広島国際大学, 薬学部, 助教 (40535580)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA KEI 広島大学, 大学院医歯薬学総合研究科, 教授 (30135032)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 位置選択的 / プロパルギルアルコール / Meyer-Schuster転位 / 4-キノロン / タンデム反応 / インドール / hypervalent / arylation / alkyne / carbamate / tandem reaction / heterocycles / indole / regioselective / copper / cyclization / benzofuran / ヨードアジデーション / α,α-ジアジドケトン / ビスマス(III)触媒 / アルキン |
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| Outline of Final Research Achievements |
We succeeded in Bi(OTf)3-catalyzed tandem Meyer-Schuster rearrangement and 1,4-addition to the resulting vinyl ketone, regioselective iodoazidation of alkynes to form α,α-Diazidoketones, tandem reaction of enynyl acetate, copper-catalyzed tandem amide N-arylation and regioselective cyclization of 2-alkynylbenzamides, and regioselective arylative ring-closing reaction of 2-alkynylphenyl derivatives to form arylated benzoxazin-2-ones, benzoxazin-2-amines and 2,3-disubstituted indoles.
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Report
(4 results)
Research Products
(23 results)
