| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The alkylative carboxylation of ynamides and allenamides with dialkylzinc reagents and carbon dioxide using a NHC-copper catalyst has been achieved. A variety of ynamides and allenamides undergo this transformation under mild conditions to afford the corresponding unsaturated carboxylic acids, which contain the dehydroamino acid skeleton. The present alkylative carboxylation formally consists of Cu-catalyzed carbozincation of ynamides with dialkylzinc reagents with the subsequent nucleophilic carboxylation of the resulting alkenylzinc species with carbon dioxide. It was also found that the carbozincation of ynamides or allenamides with alkylzinc halides and the subsequent carboxylation of the resulting alkenyl zinc species proceed smoothly in the presence of copper(I) acetylacetonate as the catalyst. In this stepwise transformation, alkylzinc halides bearing functional groups can be used to introduce a functionalized alkyl group to the carboxylation products.
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