Development of drug delivery system by using layer by layer thin films composed of electroactive moieties modified-dendrimer
Project/Area Number |
26460030
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | Takasaki University of Health and Welfare (2016) Tohoku University (2014-2015) |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 電気化学 / デンドリマー / DDS / 交互累積膜 |
Outline of Final Research Achievements |
We have demonstrated electrochemical release of nonionic polymer using 6-ferrocenylhexanethiol self assembled monolayer-modified (Fc-SAM) electrode. This result suggests a variety of nonionic polymers can be released on the electrode by electrochemical reaction. Layer by Layer (LbL) films composed of PAMAM dendrimer containing dye were prepared successfully. Release of dye was suppressed as the number of layer increased. Release rate of compounds in the films may be regulated by the number of layer. These results are useful for electrochemical drug delivery system and controlled-release membrane.
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Report
(4 results)
Research Products
(11 results)