• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel caged compound bearing off/on switch of light sensitivity

Research Project

Project/Area Number 26460032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionChiba University

Principal Investigator

Suzuki Noriyuki  千葉大学, 大学院薬学研究院, 准教授 (10376379)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords光化学反応 / caged化合物 / がん / 虚血
Outline of Final Research Achievements

Caged compounds are bioactive molecules inactivated by modification with photolabile protecting groups, and just irradiation with light to the caged compounds leads to generating corresponding bioactive molecules with highly spatial and temporal resolutions. However, spatial resolution of light is not enough for the subcellular applications of caged compounds. Therefore we developed novel photolabile groups with higher spatial resolution.
We considered that spatial resolution up to subcellular level could be achieved by switching its photosensitivity by enzymatic reactions. If a caged compound is masked its photosensitivity by enzymatically cleavable groups, specific uncaging in the targeted organella in which the reporter enzyme is localized could be achieved. We designed and synthesized novel photolabile groups, and demonstrated that photosensitivity of these compounds could be controlled by enzymatic reactions.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results,  Acknowledgement Compliant: 7 results) Presentation (19 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] Combretastatin A4-β-galactosyl conjugates for ovarian cancer prodrug monotherapy2017

    • Author(s)
      T. Doura, K. Takahashi, Y. Ogra and N. Suzuki
    • Journal Title

      ACS Med. Chem. Lett.

      Volume: 8 Issue: 2 Pages: 211-214

    • DOI

      10.1021/acsmedchemlett.6b00427

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Bioavailability comparison of nine bioselenocompounds in vitro and in vivo.2017

    • Author(s)
      K. Takahashi, N. Suzuki and Y. Ogra
    • Journal Title

      Int. J. Mol. Sci.

      Volume: - Issue: 3 Pages: 1-11

    • DOI

      10.3390/ijms18030506

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.2016

    • Author(s)
      Y. Ogra, A. Tejima, N. Hatakeyama, M. Shiraiwa, S. Wu, T. Ishikawa, A. Yawata, Y. Anan and N. Suzuki
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 33007-33007

    • DOI

      10.1038/srep33007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Construction of Bicyclo[3.2.1]octane System Carrying (R)-Carvone Core under Oxidative Radical Conditions: Synthetic Access to (+)-Miroestrols.2015

    • Author(s)
      M. Hamano, M. Akimoto, K. Funada, N. Kagawa, N. Suzuki, T. Ishikawa
    • Journal Title

      Synlett

      Volume: 26 Issue: 04 Pages: 547-551

    • DOI

      10.1055/s-0034-1379700

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Unprecedented 8,9’-Neolignans: Enantioselective Synthesis of Possible Stereoisomers for Structural Determination.2014

    • Author(s)
      M. Takahashi, N. Suzuki, T. Ishikawa, H.-Y. Huang, H.-S. Chang, I.-S. Chen.
    • Journal Title

      J. Nat. Prod.

      Volume: 77 Issue: 12 Pages: 2585-2589

    • DOI

      10.1021/np500641a

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Quantitative imaging of selenoprotein with multi-isotope imaging mass spectrometry.2014

    • Author(s)
      S.-S. Tang, C. Guillermier, M. Wang, J. C. Poczatek, N. Suzuki, J. Loscalzo, C. Lechene.
    • Journal Title

      Surf. Interface Anal.

      Volume: 46 Issue: S1 Pages: 154-157

    • DOI

      10.1002/sia.5625

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular Distribution and Behavior of Metallothionein in Mammalian Cells Following Exposure to Silver Nanoparticles and Silver Ions2014

    • Author(s)
      T. Miyayama, Y. Arai, N. Suzuki, S. Hirano.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Issue: 6 Pages: 723-729

    • DOI

      10.1248/yakushi.14-00035-1

    • NAID

      130004428000

    • ISSN
      0031-6903, 1347-5231
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] New Synthetic Procedure for 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers with Potent Antitumor Activity.2014

    • Author(s)
      S. Mkhize, N. Suzuki, A. Kurosawa, M. Fujinami, C. Chaicharoenpong, T. Ishikawa.
    • Journal Title

      Synlett

      Volume: 25 Issue: 14 Pages: 2059-2063

    • DOI

      10.1055/s-0034-1378342

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] バイオセレン化合物の変異原性評価2017

    • Author(s)
      小林 浩宜,鈴木 紀行,小椋 康光
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 血清セレンタンパク質に対するバイオセレン化合物の効果2017

    • Author(s)
      髙橋 一聡,鈴木 紀行,小椋 康光
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] セレンの酸化還元反応に基づく新規 ROS 蛍光プローブの開発2017

    • Author(s)
      鈴木 紀行,渡邉 弘樹,堂浦 智裕,小椋 康光
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化学形態別分析を基盤としたバイオセレニウム研究2016

    • Author(s)
      鈴木紀行
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 質量分析法に基づくヒ素脂質の代謝および毒性機構の解明 第1報 ~分析および抽出手法の検討~2016

    • Author(s)
      小林 弥生,鈴木紀行,小椋康光,平野 靖史郎
    • Organizer
      フォーラム2016衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] 天然由来セレン化合物の栄養的価値と生理活性の評価2016

    • Author(s)
      髙橋一聡,鈴木紀行,小椋康光
    • Organizer
      フォーラム2016衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Recent advances in analytical techniques for selenium compounds2016

    • Author(s)
      Noriyuki Suzuki, Yasumitsu Ogra
    • Organizer
      2016 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
    • Place of Presentation
      東京
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 特異的環境下で活性化される新規ケージド化合物の開発と応用2016

    • Author(s)
      鈴木紀行,久保田翔子,青木孝憲,堂浦智裕,石川勉,小椋康光
    • Organizer
      日本ケミカルバイオロシジー学会第11回年会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of Fluorescent Probe for Reactive Oxygen Species Based on Selenium Redox Reaction2016

    • Author(s)
      Hiroki Watanabe, Noriyuki Suzuki, Tomohiro Doura, Yasumitsu Ogra
    • Organizer
      The 13th International Conference on the Chemistry of Selenium and Tellurium
    • Place of Presentation
      岐阜
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthetic Study of a Novel Organoselenium Compound “Selenoneine”2016

    • Author(s)
      Koichi Endo, Noriyuki Suzuki, Tomohiro Doura, Yasumitsu Ogra
    • Organizer
      The 13th International Conference on the Chemistry of Selenium and Tellurium
    • Place of Presentation
      岐阜
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学的アプローチによるセレノリン酸の構造の再評価2016

    • Author(s)
      畠山 鉄平、鈴木 紀行、小椋 康光
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 特異的生体内環境を標的とした新規デュアルスイッチ型 caged 化合物の開発2016

    • Author(s)
      久保田翔子、青木 孝憲、堂浦 智裕、鈴木 紀行、小椋 康光
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒ素とセレンの赤血球への取り込みに関する相互作用2015

    • Author(s)
      小林 弥生、鈴木 紀行、小椋 康光、平野 靖史郎
    • Organizer
      第21回ヒ素シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 高空間分解能イメージング質量分析法によるセレノプロテインの可視化2015

    • Author(s)
      鈴木 紀行、Shiow-Shih Tang、小椋 康光
    • Organizer
      フォーラム2015衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 高空間分解能イメージング質量分析法によるセレノプロテインの可視化2015

    • Author(s)
      鈴木紀行、Shiow-Shih Tang、Claude Lechene、小椋康光
    • Organizer
      日本ケミカルバイオロジー学会第10回年会
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体微量金属に関連したバイオプローブの開発2015

    • Author(s)
      鈴木紀行
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ドラッグデリバリーシステム構築を目指した新規デュアルスイッチ型 caged 化合物の開発2015

    • Author(s)
      久保田翔子、青木孝憲、鈴木紀行、石川勉
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 特異的酵素反応により活性化される新規スイッチ式 caged 化合物の開発2014

    • Author(s)
      久保田翔子、青木孝憲、鈴木紀行、石川勉
    • Organizer
      第8回バイオ関連化学合同シンポジウム
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 特異的酵素反応によって活性化される新規ケージド化合物の開発2014

    • Author(s)
      久保田翔子、青木孝憲、鈴木紀行、石川勉
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Book] Metallomoics2017

    • Author(s)
      N. Suzuki, Y. Ogra
    • Total Pages
      364
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] スタンダード薬学シリーズII-2(物理系薬学II)2016

    • Author(s)
      鈴木紀行、他
    • Total Pages
      374
    • Publisher
      東京化学同人
    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi