Influence of genetic polymorphism on three-dimensional structure and structural flexibility of drug metabolizing enzyme

• Project/Area Number: 26460034
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Meijo University (2016); Kanazawa University (2014-2015)
• Principal Investigator: Oda Akifumi 名城大学, 薬学部, 教授 (50433511)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 薬物代謝酵素 / 遺伝多型 / 構造揺らぎ / 基質認識 / 分子動力学シミュレーション / 分子シミュレーション / 計算化学

Outline of Final Research Achievements

In this study, the influence of the genetic polymorphisms on the static three-dimensional structures and the structural flexibilities of the drug metabolizing enzymes were evaluated by using molecular simulations. The genetic polymorphisms cause the amino acid mutations in the gene product proteins, and the mutated residues cause the changes of the static and dynamic structural properties of the proteins. In the drug metabolizing enzymes, such as cytochrome P450s, the static structures of proteins changed not only around the mutated residues, but also in the distant portion of proteins because of the transformation of the hydrogen network. In addition, because the structural flexibility of proteins were changed by the mutation, the interaction between drug metabolizing enzymes and the other molecules such as water were reduced.

Research Products

• [Journal Article] Theoretical Study on Keto-enol Tautomerization of Glutarimide for Exploration of the Isomerization Reaction Pathway of Glutamic Acid in Proteins Using Density Functional Theory (2017)
  • Author(s): S. Fukuyoshi, T. Nakayoshi, O. Takahashi, A. Oda
  • Journal Title: Molecular Physics Volume: 115 Issue: 5 Pages: 560-565
  • DOI: 10.1080/00268976.2016.1232844
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Functional characterization of 34 CYP2A6 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation activities (2017)
  • Author(s): Hiroki Hosono, Masaki Kumondai, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
  • Journal Title: Drug Metabolism and Disposition Volume: 45 Issue: 3 Pages: 279-285
  • DOI: 10.1124/dmd.116.073494
  • Peer Reviewed
• [Journal Article] Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations (2017)
  • Author(s): Yurie Watanabe, Shuichi Fukuyoshi, Koichi Kato, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Hiroaki Gouda, Akifumi Oda
  • Journal Title: Journal of Molecular Graphics and Modelling Volume: 74 Pages: 326-336
  • DOI: 10.1016/j.jmgm.2017.04.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Molecular dynamics simulations to investigate the influences of amino acid mutations on protein three-dimensional structures of cytochrome P450 2D6.1, 2, 10, 14A, 51, and 62 (2016)
  • Author(s): S. Fukuyoshi, M. Kometani, Y. Watanabe, M. Hiratsuka, N. Yamaotsu, S. Hirono, N. Manabe, O. Takahashi, A. Oda
  • Journal Title: PLOS ONE Volume: 11 Issue: 4 Pages: e0152946-e0152946
  • DOI: 10.1371/journal.pone.0152946
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prediction of Three-dimensional Structures and Structural Flexibilities of Wild-type and Mutant Cytochrome P450 1A2 using Molecular Dynamics Simulations (2016)
  • Author(s): Y. Watanabe, S. Fukuyoshi, M. Hiratsuka, N. Yamaotsu, S. Hirono, O. Takahashi, A. Oda
  • Journal Title: Journal of Molecular Graphics and Modelling Volume: 68 Pages: 48-56
  • DOI: 10.1016/j.jmgm.2016.06.006
  • Peer Reviewed
• [Journal Article] Triethylated chromones with substituted naphthalenes as tubulin inhibitors (2016)
  • Author(s): Kyoko Nakagawa-Goto, Yukako Taniguchi, Yurie Watanabe, Akifumi Oda, Emika Ohkoshi, Ernest Hamel, Kuo-Hsiung Lee, Masuo Goto
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 24 Issue: 22 Pages: 6048-6057
  • DOI: 10.1016/j.bmc.2016.09.062
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring (2015)
  • Author(s): Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Bastow KF, Lee KH, Goto M
  • Journal Title: J Med Chem Volume: 58 Issue: 5 Pages: 2378-2389
  • DOI: 10.1021/jm501859j
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of initial settings on computational protein-ligand docking accuracies for several docking programs (2015)
  • Author(s): Akifumi Oda, Noriyuki Yamaotsu, Shuichi Hirono, Yurie Watanabe, Shuichi Fukuyoshi, Ohgi Takahashi
  • Journal Title: Molecular Simulation Volume: 41 Issue: 10-12 Pages: 1027-1034
  • DOI: 10.1080/08927022.2014.917300
  • Peer Reviewed
• [Journal Article] Functional characterization of 20 allelic variants of CYP1A2 (2015)
  • Author(s): Miyabi Ito, Yuki Katono, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 30 Issue: 3 Pages: 247-252
  • DOI: 10.1016/j.dmpk.2015.03.001
  • NAID: 50014429958
  • Peer Reviewed
• [Journal Article] Investigation of photoreaction for 2-nitrobenzofuran and its 3-methyl derivative (2015)
  • Author(s): Yurie Watanabe, Tomohiro Tanaka, Shuichi Fukuyoshi, Akifumi Oda
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: 311 Pages: 137-143
  • DOI: 10.1016/j.jphotochem.2015.06.024
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Carborane-containing Estrogen Receptor-beta (ERβ)-Selective Ligands (2015)
  • Author(s): Kiminori Ohta, Takumi Ogawa, Akifumi Oda, Asako Kaise, Yasuyuki Endo
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 25 Issue: 19 Pages: 4174-4178
  • DOI: 10.1016/j.bmcl.2015.08.007
  • Peer Reviewed
• [Journal Article] Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation (2015)
  • Author(s): Chiharu Tsukada, Takahiro Saito, Masamitsu Maekawa, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 30 Issue: 5 Pages: 366-373
  • DOI: 10.1016/j.dmpk.2015.07.003
  • NAID: 50014429976
  • Peer Reviewed
• [Journal Article] Estrogenic activity of bis(4-hydroxyphenyl)methanes with cyclic hydrophobic structure (2015)
  • Author(s): Tomohiro Kojima, Takumi Ogawa, Souichiro Kitao, Manabu Sato, Akifumi Oda, Kiminori Ohta, Yasuyuki Endo
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 23 Issue: 21 Pages: 6900-6911
  • DOI: 10.1016/j.bmc.2015.09.046
  • Peer Reviewed
• [Journal Article] Comparison of photoreactions of flutamide in acetonitrile and 2-propanol solvents in the absence of cage-forming compounds (2015)
  • Author(s): Yurie Watanabe, Shuichi Fukuyoshi, Akifumi Oda
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: 298 Pages: 55-61
  • DOI: 10.1016/j.jphotochem.2014.10.009
  • Peer Reviewed
• [Journal Article] Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation (2015)
  • Author(s): M. Takahashi, T. Saito, M. Ito, C. Tsukada, Y. Katono, H. Hosono, M. Maekawa, M. Shimada, N. Mano, A. Oda, N. Hirasawa, M. Hiratsuka
  • Journal Title: The Pharmacogenomics Journal Volume: 15 Issue: 1 Pages: 26-32
  • DOI: 10.1038/tpj.2014.30
  • Peer Reviewed
• [Journal Article] Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors. (2015)
  • Author(s): 2.Saijo, K.，Imamura, J.，Narita, K.，Oda, A.，Shimodaira, H.，Katoh, T.，Ishioka, C.
  • Journal Title: Cancer Sci Volume: 106 Issue: 2 Pages: 208-215
  • DOI: 10.1111/cas.12585
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Predicting three-dimensional conformations of peptides constructed of only glycine, alanine, aspartic acid, and valine (2015)
  • Author(s): Akifumi Oda, Shuichi Fukuyoshi
  • Journal Title: Origins of Life and Evolution of Biospheres Volume: 印刷中 Issue: 1-2 Pages: 183-193
  • DOI: 10.1007/s11084-015-9418-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening (2015)
  • Author(s): Akifumi Oda, Ikuhiko Noji, Shuichi Fukuyoshi, Ohgi Takahashi
  • Journal Title: Journal of Pharmaceutical and Biomedical Analysis Volume: 印刷中 Pages: 116-122
  • DOI: 10.1016/j.jpba.2015.02.030
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach. (2014)
  • Author(s): Oda, A.，Saijo, K.，Ishioka, C.，Narita, K.，Katoh, T.，Watanabe, Y.，Fukuyoshi, S.，Takahashi, O.
  • Journal Title: J Mol Graph Model Volume: 54 Pages: 46-53
  • DOI: 10.1016/j.jmgm.2014.08.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for <i>N</i>-Desmethyltamoxifen 4-Hydroxylation Activity (2014)
  • Author(s): Yuka Muroi, Takahiro Saito, Masamitsu Takahashi, Kanako Sakuyama, Yui Niinuma, Miyabi Ito, Chiharu Tsukada, Kiminori Ohta, Yasuyuki Endo, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 29 Issue: 5 Pages: 360-366
  • DOI: 10.2133/dmpk.DMPK-14-RG-014
  • NAID: 130004463395
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Presentation] A computational study of racemization mechanism of aspartate residue catalyzed by phosphate ion (2017)
  • Author(s): Tomoki Nakayoshi, Shuichi Fukuyoshi, Ohgi Takahashi, Akifumi Oda
  • Organizer: The 57th Sanibel Symposium
  • Place of Presentation: St. Simons Island （USA）
  • Int'l Joint Research
• [Presentation] Evaluations of Density Functionals and Solvation Effect for Racemization Reaction of Amino Acid Residues (2017)
  • Author(s): Shuichi Fukuyoshi, Tomoki Nakayoshi, Ohgi Takahashi, Akifumi Oda
  • Organizer: The 57th Sanibel Symposium
  • Place of Presentation: St. Simons Island （USA）
  • Int'l Joint Research
• [Presentation] ドッキングポーズの選別を分子動力学シミュレーションによって行うことは可能か (2017)
  • Author(s): 小田彰史、福吉修一、栗本英治
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
• [Presentation] 酵母輸送タンパク質Emp46p/47p コイルドコイルドメインのpH 依存的複合体形成における機能セグメントの抽出 (2017)
  • Author(s): 加藤紘一、池畑美帆、小田彰史、栗本英治
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
• [Presentation] ヒトプロテアソームα 6, α 7 サブユニットにより形成されるリングを応用したタンパク質の集積化 (2017)
  • Author(s): 栗本英治、神藤彩加、橋本友佳、小田彰史
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
• [Presentation] 分子動力学シミュレーションを用いたCYP1A2の基質認識における水分子の役割の予測 (2016)
  • Author(s): 渡邉友里江、福吉修一、平塚真弘、山乙教之、広野修一、小田彰史
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2016-03-29
• [Presentation] Theoretical study on keto-enol tautomerization of glutarimide for exploration of the isomerization reaction pathway of glutamic acid in proteins using density functional theory (2016)
  • Author(s): Shuichi Fukuyoshi, Tomoki Nakayoshi, Ohgi Takahashi, Akifumi Oda
  • Organizer: 56th Sanibel Symposium
  • Place of Presentation: King and Prince Hotel, St. Simons Island (USA)
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] Evaluations of Force Field Parameters for D-Amino Acid Residues Using Density Functional Theory (2016)
  • Author(s): Akifumi Oda, Ohgi Takahashi, Shuichi Fukuyoshi
  • Organizer: 56th Sanibel Symposium
  • Place of Presentation: King and Prince Hotel, St. Simons Island (USA)
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] ヒトプロテアソームα6,α7サブユニットにより形成されるリングをベースとしたタンパク質の集積化 (2016)
  • Author(s): 神藤彩加、石原利紗、小田彰史、栗本英治
  • Organizer: 第62回日本薬学会東海支部大会
  • Place of Presentation: 愛知学院大学（愛知県名古屋市）
• [Presentation] CONFORMATIONAL ENERGIES AND MOLECULAR FORCE FIELD PARAMETERS FOR NITRONYL NITROXIDE OBTAINED BY QUANTUM CHEMICAL CALCULATIONS (2016)
  • Author(s): Akifumi Oda, Shuichi Fukuyoshi
  • Organizer: The 15th International Conference on Molecule-Based Magnets
  • Place of Presentation: Sendai International Center （Sendai）
  • Int'l Joint Research
• [Presentation] 全ゲノム解析から同定された CYP2C9レアバリアント解析評価 (2016)
  • Author(s): 伊藤暁生、齋藤雄大、長﨑正朗、齋藤さかえ、安田純、小田彰史、平澤典保、平塚真弘
  • Organizer: 第55回日本薬学会東北支部大会
  • Place of Presentation: 奥羽大学（福島県郡山市）
• [Presentation] 酵母輸送タンパク質Emp46p/47pのコイルドコイルのプロリン変異によるpH依存的会合特性の変化 (2016)
  • Author(s): 加藤紘一、古橋隆久、小田彰史、栗本英治
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際会議場（宮城県仙台市）
• [Presentation] 日本人集団で新規に同定されたCYP2C19遺伝子多型バリアントの機能評価 (2016)
  • Author(s): 齋藤雄大、高橋理充、小田彰史、前川正充、三枝大輔、平澤典保、平塚真弘
  • Organizer: 日本薬物動態学会第31回年会
  • Place of Presentation: キッセイ文化ホール（長野県松本市）
• [Presentation] CYP2A6遺伝子多型バリアント酵素の機能変化 (2016)
  • Author(s): 公文代將希、細野寛貴、前川正充、小田彰史、平澤典保、平塚真弘
  • Organizer: 日本薬物動態学会第31回年会
  • Place of Presentation: キッセイ文化ホール（長野県松本市）
• [Presentation] Analysis for assembling mechanism of coiledcoil domains in yeast cargo receptor Emp46p/47p and modification of pH-dependence for the complex formation (2016)
  • Author(s): Koichi KATO, Takahisa FURUHASHI, Eiji, KURIMOTO, Akifumi ODA
  • Organizer: 第44回構造活性相関シンポジウム
  • Place of Presentation: 京都大学（京都府京都市）
• [Presentation] Evaluation of the structural features between estrogen receptor alpha and beta using molecular dynamics simulations (2016)
  • Author(s): Kenichiro FUJII, Shuichi FUKUYOSHI, Noriyuki YAMAOTSU, Shuichi HIRONO, Akifumi ODA
  • Organizer: 第44回構造活性相関シンポジウム
  • Place of Presentation: 京都大学（京都府京都市）
• [Presentation] Evaluation of structual differences between estrogen receptor α and β using the ligand binding site search program HBOP/HBSITE (2015)
  • Author(s): Kenichiro Fujii, Shuichi Fukuyoshi, Noriyuki Yamaotsu, Shuichi Hirono, Akifumi Oda
  • Organizer: Pacifichem 2015
  • Place of Presentation: Hawaii Convention Center,Honolulu (USA)
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] Structural prediction of wild-type and mutant CYP1A2 complexed with 7-ethoxyresorufin using docking and molecular dynamics simulations (2015)
  • Author(s): Yurie Watanabe, Shuichi Fukuyoshi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Akifumi Oda
  • Organizer: Pacifichem 2015
  • Place of Presentation: Hawaii Convention Center,Honolulu (USA)
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] Solvent and substituent effect on lifetime of colored form of dinitrobenzylpyridine derivatives (2015)
  • Author(s): Shuichi Fukuyoshi, Tomoki Nakayoshi, Yurie Watanabe, Akifumi Oda
  • Organizer: Pacifichem 2015
  • Place of Presentation: Hawaii Convention Center,Honolulu (USA)
  • Year and Date: 2015-12-17
  • Int'l Joint Research
• [Presentation] Structural predictions of primitive proteins including only limited types of amino acids (2015)
  • Author(s): Akifumi Oda
  • Organizer: 8th Astrobiology Workshop
  • Place of Presentation: 東京工業大学（東京）
  • Year and Date: 2015-11-28
  • Int'l Joint Research / Invited
• [Presentation] Investigation of the substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations (2015)
  • Author(s): 渡邉友里江, 福吉修一, 平塚真弘, 山乙教之, 広野修一, 小田彰史
  • Organizer: 第43回構造活性相関シンポジウム
  • Place of Presentation: 新潟日報メディアシップ（新潟）
  • Year and Date: 2015-09-29
• [Presentation] Structural comparison between wild-type and mutant N-acetyltransferase 2 using molecular dynamics simulation (2015)
  • Author(s): 村田瑛理子，福吉修一，山乙教之，広野修一，小田彰史
  • Organizer: 第43回構造活性相関シンポジウム・第10回薬物の分子設計と開発に関する日中シンポジウム
  • Place of Presentation: 新潟日報メディアシップ（新潟）
  • Year and Date: 2015-09-28
  • Int'l Joint Research
• [Presentation] D-アミノ酸のための分子力場パラメータの開発および評価 (2015)
  • Author(s): 小田彰史、福吉修一、高橋央宜
  • Organizer: 第11回D-アミノ酸学会学術講演会
  • Place of Presentation: シティホールプラザアオーレ長岡（長岡）
  • Year and Date: 2015-08-25
• [Presentation] Influence of Genetic Polymorphism on Complex Structure of CYP1A2 with 7-Ethoxyresorufin Predicted by Docking and Molecular Dynamics Simulation (2015)
  • Author(s): Yurie Watanabe, Shuichi Fukuyoshi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Akifumi Oda
  • Organizer: 19th International Conference on Cytochrome P450
  • Place of Presentation: National Olympics Memorial Youth Center (Tokyo)
  • Year and Date: 2015-06-13
  • Int'l Joint Research
• [Presentation] 小さいタンパク質の立体構造および二次構造を分子動力学法で予測できるか？ (2015)
  • Author(s): 小田彰史、福吉修一
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸サンボーホール（神戸）
  • Year and Date: 2015-03-27
• [Presentation] カルボランのAMBER力場パラメータの開発 (2014)
  • Author(s): 小田彰史、太田公規、遠藤泰之、福吉修一
  • Organizer: 第37回情報化学討論会
  • Place of Presentation: 豊橋商工会議所（豊橋）
  • Year and Date: 2014-11-28
• [Presentation] 分子動力学法による小さいタンパク質の立体構造の推定 (2014)
  • Author(s): 小田彰史、福吉修一
  • Organizer: 第42回構造活性相関シンポジウム
  • Place of Presentation: くまもと森都心プラザ （熊本）
  • Year and Date: 2014-11-13
• [Presentation] PREDICTION OF THREE-DIMENSIONAL STRUCTURES AND STRUCTURAL FLEXIBILITIES OF WILD-TYPE AND MUTANT CYTOCHROME P450 1A2 BY MOLECULAR DYNAMICS SIMULATIONS (2014)
  • Author(s): Yurie Watanabe, Shuichi Fukuyoshi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Akifumi Oda
  • Organizer: 19th North American ISSX Meeting and 29th JSSX Annual Meeting
  • Place of Presentation: Hilton San Francisco, San Francisco (USA)
  • Year and Date: 2014-10-19 – 2014-10-23
• [Presentation] 野生型および変異型CYP2B6 の柔らかさが薬物代謝に与える影響の推定 (2014)
  • Author(s): Akifumi Oda, Kana Kobayashi, Yurie Watanabe, Shuichi Fukuyoshi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Ohgi Takahashi
  • Organizer: 第52回日本生物物理学会年会
  • Place of Presentation: 札幌コンベンションセンター（札幌）
  • Year and Date: 2014-09-27
• [Presentation] PREDICTIONS OF BINDING MODES BETWEEN PROTEIN L-ISOASPARTYL (D-ASPARTYL) O-METHYLTRANSFERASE AND LIGANDS (2014)
  • Author(s): Akifumi ODA, Ikuhiko NOJI, Shuichi FUKUYOSHI, Ohgi TAKAHASHI
  • Organizer: The 2nd International Conference of D-Amino Acid Research
  • Place of Presentation: Tochigi Prefectural Culture Center (Utsunomiya)
  • Year and Date: 2014-09-03
• [Presentation] Investigations for Conformations of [GADV]-peptides Using Molecular Dynamics Simulations (2014)
  • Author(s): Akifumi Oda, Shuichi Fukuyoshi
  • Organizer: Origins 2014
  • Place of Presentation: Nara Prefecture New Public Hall (Nara)
  • Year and Date: 2014-07-08
• [Remarks] 生物物理化学研究室｜名城大学 薬学部
  • URL: http://www-yaku.meijo-u.ac.jp/kenkyu/biophysical/
• [Remarks] 金沢大学 活性相関物理化学研究室
  • URL: http://www.p.kanazawa-u.ac.jp/~bukka/