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Nanoparticle-based pulmonary drug delivery system to extend the nanomedicine

Research Project

Project/Area Number 26460040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionNagoya City University

Principal Investigator

Tetsuya Ozeki  名古屋市立大学, 大学院薬学研究科, 教授 (60277259)

Co-Investigator(Kenkyū-buntansha) 田上 辰秋  名古屋市立大学, 大学院薬学研究科, 講師 (10609887)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsナノコンポジット粒子 / 経肺投与 / ドラッグデリバリーシステム / 吸入剤 / 機能性ナノ粒子 / 金ナノ粒子 / 経肺投与型製剤
Outline of Final Research Achievements

Various kinds of nanoparticle-based formulations, which are termed as nanomedicine, have been developing among researchers. However, most of nanomedicine is applied for intravenous injection and the administration route is a limitation for the principal use of nanomedicine. I have been developing various nanocomposite particles (microparticles containing functional nanoparticles) by using spray drying technology. The functional nanoparticles are expecting for not only lung-related diseases but also systemic diseases by passing through alveolar endothelial cells layer which is in the deepest lung tissue. I developed the composite particles containing ultra small gold nanoparticles or curcumin as poorly water soluble compound and then the nanocomposite particles were evaluated.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Fabrication of nanocomposite particles using a two-solution mixing type spray nozzle for use in an inhaled curcumin formulation2016

    • Author(s)
      Moeko Taki, Tatsuaki Tagami, Kaori Fukushige, Tetsuya Ozeki
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 511 Issue: 1 Pages: 104-110

    • DOI

      10.1016/j.ijpharm.2016.06.134

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] Characterization of gold nanoparticles included in high density lipoprotein-mimetic nanoparticles for the treatment of vascular inflammation2015

    • Author(s)
      Akihiro Hoshikawa, Tatsuaki Tagami, Tetsuya Ozeki
    • Organizer
      2015 AAPS Annual Meeting and Exposition
    • Place of Presentation
      Orange County Convention Center, Orlando, Florida, USA
    • Year and Date
      2015-11-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 金ナノ粒子を核とした人工HDL製剤調製において還元剤が粒子調製に及ぼす影響2015

    • Author(s)
      星川晃宏, 田上辰秋, 尾関哲也
    • Organizer
      平成27年度粉体工学会 機能性ナノ・マイクロ粒子の設計とプロセス制御に関するワークショップ
    • Place of Presentation
      ホテルグッディ大垣(岐阜県大垣市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 金ナノ粒子を基盤とした人工HDL製剤における核粒子物性の評価2015

    • Author(s)
      星川晃宏, 田上辰秋, 尾関哲也
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 経肺投与型金ナノ粒子製剤の調製と肺組織内分散安定性に関する検討2015

    • Author(s)
      石亀貴欣, 田上辰秋, 尾関哲也
    • Organizer
      日本薬剤学会第30年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 高密度siRNA搭載金ナノ粒子が新生血管の伸展に与える影響2014

    • Author(s)
      竹内堂朗、福重香、田上辰秋、尾関哲也
    • Organizer
      2014年度京都薬科大学私立大学戦略的研究基盤形成支援事業合同成果発表会
    • Place of Presentation
      京都薬科大学 (京都府京都市)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 粒子径制御を目的とした1-octadecanethiol表面修飾金ナノ粒子調製法の基礎的検討2014

    • Author(s)
      星川晃宏、高橋朋弘、田上辰秋、尾関哲也
    • Organizer
      製剤機械技術学会第24回大会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 金ナノ粒子含有マイクロ粒子調製における賦形剤の物性に与える影響2014

    • Author(s)
      石亀貴欣、田上辰秋、尾関哲也
    • Organizer
      平成26年度 粉体工学会 粒子の流動化・分散を利用した粉体製品開発に関するワーク ショップ
    • Place of Presentation
      岐阜県土岐市
    • Year and Date
      2014-09-29 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 経肺投与に適した金ナノ粒子含有マイクロ粒子の製剤設計2014

    • Author(s)
      石亀貴欣、田上辰秋、尾関哲也
    • Organizer
      第30回日本DDS学会学術集会
    • Place of Presentation
      慶応義塾大学 (東京都港区)
    • Year and Date
      2014-07-30 – 2014-07-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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