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Controlled disposition of tacrolimus in skin with atopic dermatitis using stimulus-responsible rotaxane nanoparticles

Research Project

Project/Area Number 26460042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionJosai University

Principal Investigator

SEKI TOSHINOBU  城西大学, 薬学部, 教授 (60196946)

Co-Investigator(Renkei-kenkyūsha) MIKI Ryotaro  城西大学, 薬学部, 助手 (20635437)
Research Collaborator HAZAMA Yutaro  
TANAKA Yuya  
MAEKAWA Toshihisa  
UCHIDA Wataru  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords皮膚内動態 / 経皮吸収 / タクロリムス / シクロデキストリン / 刺激応答性 / 皮膚適用 / 全身性副作用 / 微粒子化
Outline of Final Research Achievements

Tacrolimus (TL) is used topically for atopic dermatitis (AD) treatment. AD skin shows various physiological alterations. Our study using animal models showed alterations of skin barrier function and skin blood flow affected on systemic absorption of TL. We used TL ointment (0.1% ointment) with or without adrenaline (Adr, 0.5 w/w%) in order to suppress systemic absorption of TL. Skin barrier dysfunction correlated positively with systemic absorption of TL in AD skin, and dilution of TL ointment suppressed TL absorption. Although skin blood flow affected on TL absorption as skin barrier disrupted, relation between skin blood flow and TL absorption, and effect of combined-use of Adr were unclear. Relation between blood and skin disposition of TL was biphasic, suggesting bounding saturation of TL to skin tissue.
In order to control disposition of TL in skin, carriers were design. Cyclodextrin derivatives were useful to regulate penetration rate of TL through model membranes.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Effect of physiological changes in the skin on systemic absorption of tacrolimus following topical application in rats2016

    • Author(s)
      Yutaro Hazama, Toshihisa Maekawa, Ryotaro Miki, Shinji Oshima, Yuya Egawa, Kazuhiro Morimoto, Toshinobu Seki
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 39 Pages: 343-352

    • NAID

      130005132307

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Presentation] タクロリムス皮膚適用後の全身移行性と局所滞留性のラットを用いた評価2016

    • Author(s)
      前川 俊久、間 祐太朗、内田 亘、武井 千弥、小林 由希、三木 涼太郎、大島 新司、江川 祐哉、関 俊暢
    • Organizer
      日本薬剤学会第31年会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] アトピー性皮膚炎モデルマウスを用いたタクロリムス軟膏皮膚適用後の全身および皮膚局所移行性に及ぼす皮膚状態の影響2016

    • Author(s)
      間 祐太朗、内田 亘、前川 俊久, 三木 涼太郎、大島 新司、江川 祐哉、関 俊暢
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリロタキサン構造を利用した新規薬物担体調製の試み2016

    • Author(s)
      内田 亘、三木 涼太郎、江川 祐哉、関 俊暢
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] マイクロダイアリシス法による皮膚中タクロリムス濃度の新規測定法に関する検討2016

    • Author(s)
      田中 雄也、前川 俊久、間 祐太朗、三木 涼太郎、江川 祐哉、関 俊暢
    • Organizer
      第27回マイクロダイアリシス研究会
    • Place of Presentation
      文京区
    • Related Report
      2016 Annual Research Report
  • [Presentation] タクロリムス皮膚適用後の全身移行性に及ぼす皮膚状態の変化と血管収縮薬の影響2015

    • Author(s)
      前川 俊久、間 祐太朗、三木 涼太郎、大島 新司、江川 祐哉、関 俊暢
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      船橋
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] タクロリムス軟膏剤の全身性副作用の回避を目的とした皮膚内吸収動態の検討2015

    • Author(s)
      間 祐太朗、前川 俊久、Patel Avnish、三木 涼太郎、大島 新司、江川 祐哉、Lane Majella
    • Organizer
      日本薬剤学会第30年会、学生シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 皮膚適用後のタクロリムスの全身吸収への血管収縮剤の影響2015

    • Author(s)
      前川 俊久、増田 裕行、間 祐太朗、三木 涼太郎、大島 新司、江川 祐哉、関 俊暢
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] シクロデキストリンによるタクロリムスの皮膚内動態制御の試み2015

    • Author(s)
      内田 亘、間 祐太朗、前川 俊久、三木 涼太郎、江川 祐哉、関 俊暢
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮膚微小循環の変化がタ クロリムス経皮吸収動態に及ぼす影響2014

    • Author(s)
      前川俊久、間祐太朗、三木涼太郎、大島新司、江川祐哉、関俊暢
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      町田市
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 種々炎症モデルヘアレスラットにおけるタクロリムス皮膚内動態の解析2014

    • Author(s)
      間祐太朗、増田裕行、三木涼太郎、大島新司、江川祐哉、関俊暢
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      さいたま市
    • Year and Date
      2014-05-20 – 2014-05-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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