Exploring pharmaceutical cocrystals in nanogram order by using microscpic Raman spectroscopy
| Project/Area Number |
26460045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
尾関 哲也 名古屋市立大学, 大学院薬学研究科, 教授 (60277259)
井上 元基 明治薬科大学, 薬学部, 助教 (90722950)
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| Research Collaborator |
Carriere James Ondax Inc.
Heyler Randy Ondax Inc.
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 共結晶 / コクリスタル / cocrystal / 探索スクリーニング / ラマン分光法 / 顕微ラマン / 医薬品共結晶 / 低波数ラマン分光法 |
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| Outline of Final Research Achievements |
Pharmaceutical cocrystals are promising technique to improve the solid physicochemical properties of active pharmaceutical ingredients without modification of its chemical structure. In this study, a screening method for exploring novel cocrystals was developed, which required very small amount of samples. Fundamental technology was established and feasibility test was successfully demonstrated including installation of automatic system by 2015. This result was published in scientific journal of Royal Chemical Society in 2016. There were some additional improvement relating Raman spectroscopy and screening technique during these study.
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Report
(4 results)
Research Products
(27 results)
