| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Residual stress distributions of tablets were estimated by the computer-aided engineering (CAE) technique, and their effects on the critical quality attributes (CQA) of tablets were investigated. Powders or granules composed of pharmaceutical active ingredients and typical excipients were prepared, and their compression process was defined by the Drucker-Prager cap (DPC) model. The DPC parameters were fed into the analysis using the finite element method, and the residual stress distribution of tablets was estimated. As a result, CQA values such as the tensile strength and the disintegration time were well predicted by the remained stress distribution, suggesting capabilities of CAE simulation on the tablet manufacturing process.
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