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Development of an analytical method for quickly determining synthetic cannabinoids comprehensively designated against the problem of illegal herbal drugs

Research Project

Project/Area Number 26460049
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionHoshi University

Principal Investigator

Saito Koichi  星薬科大学, 薬学部, 教授 (40386347)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsanalytical chemistry / forensic science / illegal drugs / 危険ドラッグ / 脱法ハーブ / 迅速分析 / GC/MS / LC/TOF-MS / 合成カンナビノイド / ヘッドスペース固相マイクロ抽出 / DART-TOFMS / 光イオン化-GC/MS
Outline of Final Research Achievements

In order to cope with the abused drug problem of so-called "illegal herbal drugs", the analysis methods of synthetic cannabinoids contained in the illegal herbal drugs were developed by using an LC/TOF-MS and a headspace solid-phase microextraction (HS-SPME)-GC/MS.
Furthermore, considering crime of use, we examined the construction of analysis methods for synthetic cannabinoids in blood (serum and whole blood). As a result, the LC/TOF-MS and HS-SPME-GC/MS methods developed allowed the simple and rapid screening analysis of the synthetic cannabinoids in blood. These results indicate that this research is expected to be applicable for the fiels of forensic science in the near future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] 光イオン化ガスクロマトグラフィー/質量分析法による危険ドラッグおよびデータベースの構築2017

    • Author(s)
      阿久津守、杉江謙一、斉藤貢一
    • Journal Title

      分析化学

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of 62 synthetic cannabinoids by gas chromatography-mass spectrometry with photoionization2017

    • Author(s)
      Mamoru Akutsu, Ken-ichi Sugie, Koichi Saito
    • Journal Title

      Forensic Toxicology

      Volume: 35 Issue: 1 Pages: 99-103

    • DOI

      10.1007/s11419-016-0342-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Quantitative Analysis of NPS (New Psychoactive Substance) Containing α-PVP by Direct Analysis in Real Time (DART)-TOF-MS with Micro Syringe Injection2016

    • Author(s)
      杉江 謙一, 阿久津 守, 斉藤 貢一
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 65 Issue: 8 Pages: 439-446

    • DOI

      10.2116/bunsekikagaku.65.439

    • NAID

      130006846976

    • ISSN
      0525-1931
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples2014

    • Author(s)
      SAITO, K., KIKUCHI, Y., SAITO, R.
    • Journal Title

      J. Pharm. Biomed. Anal.

      Volume: 49 Pages: 331-335

    • DOI

      10.1016/j.jpba.2014.07.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 危険ドラッグ(脱法ハーブ)使用者の診断に当たっての問題点2016

    • Author(s)
      柳川洋一, 日域佳, 竹内郁人, 竹内郁人,石川浩平,大森一彦,大阪裕通,斉藤貢一
    • Organizer
      第38回日本中毒学会総会・学術集会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生体試料中の薬毒物分析における前処理操作としての固相分散抽出法の有用性2016

    • Author(s)
      斉藤貢一,伊藤里恵
    • Organizer
      日本法中毒学会35年会
    • Place of Presentation
      大阪産業創造館
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 違法薬物の分析2016

    • Author(s)
      斉藤貢一
    • Organizer
      第76回分析化学討論会
    • Place of Presentation
      岐阜薬科大学
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヘッドスペース-固相マイクロ抽出-GC/MSを用いた血液中合成カンナビノイドの検出2016

    • Author(s)
      金子聡美,古屋柚香,浅田優美,伊藤里恵,斉藤貢一
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] LC/TOF-MSによる血清・全血中合成カンナビノイドの一斉分析2016

    • Author(s)
      村中優希,藤澤美希,小鍛治好恵,伊藤里恵,斉藤貢一
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] ベンゾジアゼピン系薬物の人工胃液中における安定性および液性変化に伴う分解中間体の可逆的な回復挙動の検証2015

    • Author(s)
      斉藤貢一,齋藤沙知,西山莉可,伊藤里恵
    • Organizer
      日本法科学技術学会第21回学術集会
    • Place of Presentation
      柏の葉カンファレンスセンター
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] α-PVP含有危険ドラッグのDART-TOF MSによる高精度な定量分析法の検討2015

    • Author(s)
      杉江謙一,阿久津守,斉藤貢一
    • Organizer
      日本法科学技術学会第21回学術集会
    • Place of Presentation
      柏の葉カンファレンスセンター
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 乱用薬物分析における試料前処理法2015

    • Author(s)
      斉藤貢一
    • Organizer
      日本分析化学会第64年会
    • Place of Presentation
      九州大学伊都キャンパスセンターゾーン
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 固相分散抽出法および固相蛍光誘導体化法を用いたHPLC による血清中のエフェドリンとプソイドエフェドリンの微量分析2015

    • Author(s)
      斉藤貢一,川上 彩香,伊藤 里恵
    • Organizer
      日本法中毒学会第34年会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 合成カンナビノイド分析における光イオン化(PI)GC/MSの有用性の検討2015

    • Author(s)
      阿久津守,杉江謙一,斉藤貢一
    • Organizer
      日本法中毒学会第34年会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] LC/TOF-MSによる脱法ハーブ中合成カンナビノイドの一斉分析および保持時間の線形予測解析2015

    • Author(s)
      藤澤 美希
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] LC/TOF-MSによる合成カンナビノイド類の一斉分析および保持時間の線形予測解析2014

    • Author(s)
      斉藤 貢一
    • Organizer
      日本法中毒学会第33年会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Remarks] 星薬科大学 薬品分析化学教室 研究業績

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/bunseki/publications.html#p02

    • Related Report
      2015 Research-status Report
  • [Remarks] 星薬科大学薬品分析化学教室ホームページ

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/bunseki/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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