Control of Crystal Polymorph Transition and Morphology Utilizing Cyclodextrin Complexation
| Project/Area Number |
26460054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
庵原 大輔 崇城大学, 薬学部, 講師 (40454954)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | シクロデキストリン / 結晶多形 / 包接複合体 / プロスタグランジン / 結晶化 / 非晶質複合体 / 安定化 / モルホロジー / ゲル / 多形転移 |
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| Outline of Final Research Achievements |
In this study, we conducted the crystallization of prostaglandin E1 from its amorphous α- and β-cyclodextrin inclusion compounds and the stabilizations of their amorphous state of the drug and the chemical stability of the drug by a combination of α- and β-cyclodextrins. Further, X-ray structure analyses of crystals of the isosorbide/β-cyclodextrin complex was conducted to gain insight into polymorphism for cyclodextrin inclusion complexes. The β-CyD-appended polyacrylic acids were prepared to gain insight into crystallization of drugs in polymeric gels containing β-cyclodextrin.
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Report
(4 results)
Research Products
(7 results)
