| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
In this study, we conducted the crystallization of prostaglandin E1 from its amorphous α- and β-cyclodextrin inclusion compounds and the stabilizations of their amorphous state of the drug and the chemical stability of the drug by a combination of α- and β-cyclodextrins. Further, X-ray structure analyses of crystals of the isosorbide/β-cyclodextrin complex was conducted to gain insight into polymorphism for cyclodextrin inclusion complexes. The β-CyD-appended polyacrylic acids were prepared to gain insight into crystallization of drugs in polymeric gels containing β-cyclodextrin.
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