| Project/Area Number |
26460055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2016)
Japan Atomic Energy Agency (2014-2015) |
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Principal Investigator |
Adachi Motoyasu 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (60293958)
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| Research Collaborator |
SHIMIZU Rumi 国立研究開発法人量子科学技術研究開発機構, 量子ビーム科学研究部門・高崎量子応用研究所・東海量子ビーム応用研究センター, 主任技術員
SHIBAZAKI Chie 国立研究開発法人量子科学技術研究開発機構, 量子ビーム科学研究部門・高崎量子応用研究所・東海量子ビーム応用研究センター, 任期付研究員
KAGOTANI Yuji 国立研究開発法人量子科学技術研究開発機構, 量子ビーム科学研究部門・高崎量子応用研究所・東海量子ビーム応用研究センター, 派遣職員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HIVプロテアーゼ / 薬剤耐性 / 不活性化酵素 / 結晶構造解析 |
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| Outline of Final Research Achievements |
Emergence of drug resistant virus is one of the serious medical issues. Human immune deficiency virus protease (HIVPR) derived from A17 virus strain exhibits the complicated characteristics in decreasing affinity to inhibitors of Ritonavir (RTV), Lopinavir (LPV). In this study, interactions of protease with substrates and inhibitors were investigated by i) high resolution X-ray and neutron crystallography, and ii) isothermal titration calorimetry to reveal molecular mechanism in drug resistance of a virus Acid protease, HIVPR. The designed HIV-PR will be useful to design the new effective inhibitors and medicines.
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