| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The pH of normal tissues is known to be higher than that of tumors. It is also known that radiation damages are mainly caused by reactive oxygen species (ROS) generated via ionization and/or excitation of water molecules by ionizing radiation. Thus, pH responsive antioxidants that can selectively scavenge ROS in normal tissues were investigated to protect normal tissues from radiation damage during cancer radiotherapy. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radial is frequently used as a reactivity model of ROS to evaluate activity of antioxidants. However, the insolubility of DPPH radical in water has precluded from its use in aqueous systems. In this study, DPPH radical was successfully solibilized in water using a cyclodextrin. This enables us to investigate the effect of pH on the radical-scavenging rates of water-soluble antioxidants in order to develop radioprotectors, which can selectively protect normal tissues from the radiation damages during radiotherapy.
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