Functional analysis of senescence-Associated T cells (SA-T)
| Project/Area Number |
26460066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Keio University (2015-2017)
Kyoto University (2014) |
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Principal Investigator |
INOUE Joe 慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 (00433714)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 免疫老化 / 自己免疫疾患 / 胚中心 / がん |
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| Outline of Final Research Achievements |
Our group has found and identified senescence-associated T cells (SA-T) which increase with age. In this study, the functions of SA-T in aged mice and various disease model mice were analyzed. Increase of SA-T and increase of germinal center reaction were confirmed in aged mice, and auto-antibody increased in some individuals. Similarly, NZB / W-F1 mouse, an autoimmune disease model mouse, showed an increase in SA-T, an increase in germinal center reaction and auto-antibody production from young age as compared with wild type mouse. Interestingly, analysis of mice lacking B cells revealed that there was almost no SA-T despite being an aged individual.
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Report
(5 results)
Research Products
(6 results)
