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Functional analysis of senescence-Associated T cells (SA-T)

Research Project

Project/Area Number 26460066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKeio University (2015-2017)
Kyoto University (2014)

Principal Investigator

INOUE Joe  慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 (00433714)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords免疫老化 / 自己免疫疾患 / 胚中心 / がん
Outline of Final Research Achievements

Our group has found and identified senescence-associated T cells (SA-T) which increase with age. In this study, the functions of SA-T in aged mice and various disease model mice were analyzed. Increase of SA-T and increase of germinal center reaction were confirmed in aged mice, and auto-antibody increased in some individuals. Similarly, NZB / W-F1 mouse, an autoimmune disease model mouse, showed an increase in SA-T, an increase in germinal center reaction and auto-antibody production from young age as compared with wild type mouse. Interestingly, analysis of mice lacking B cells revealed that there was almost no SA-T despite being an aged individual.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Synthetic Biomarker Design Using Analyte-Responsive Acetaminophen2017

    • Author(s)
      Nishihara, T. Inoue, J. Tabata, S. Murakami, S. Ishikawa, T. Saito, N. Fukuda, S. Tomita, M. Soga, T.
    • Journal Title

      Chembiochem

      Volume: in press Issue: 10 Pages: 1-5

    • DOI

      10.1002/cbic.201700023

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production.2015

    • Author(s)
      1.Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.
    • Journal Title

      The Journal of Immunology

      Volume: 194 Issue: 12 Pages: 5725-5735

    • DOI

      10.4049/jimmunol.1500319

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modification of Gene Expression, Proliferation, and Function of OP9 Stroma Cells by Bcr-Abl-Expressing Leukemia Cells2015

    • Author(s)
      Supper E, Tahir S, Imai T, Inoue J, Minato N.
    • Journal Title

      PLoS One

      Volume: 10(7) Issue: 7 Pages: e0134026-e0134026

    • DOI

      10.1371/journal.pone.0134026

    • NAID

      120005678188

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.2015

    • Author(s)
      Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N.
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 7978-7985

    • DOI

      10.1038/srep07978

    • NAID

      120005555511

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Rap1/SPA-1によるNKT細胞の分化制御2015

    • Author(s)
      井上浄、濱崎洋子、湊長博
    • Organizer
      Kyoto T cell Conference
    • Place of Presentation
      京都:京都大学 芝蘭会館
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Senescence associated follicular CD4+T cell population underlies systemic lupus erythematosus2014

    • Author(s)
      Suhail TAHIR, Yuji FUKUSHIMA, Keiko SAKAMOTO, Kyosuke SATO, Joe INOUE, Masakazu HATTORI, Yoko HAMAZAKI, Nagahiro MINATO
    • Organizer
      第43回 日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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