| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Vesicular nucleotide transporter (VNUT) is responsible for vesicular storage and release of ATP, and is essential for purinergic chemical transmission. The aim of this research project was to reveal the molecular mechanism of vesicular ATP release and its physiological significance in nervous and endocrine systems. We showed that VNUT knockout mice improve hyperglycemia, insulin resistance, inflammatory and neuropathic pain, and the accompanying inflammation. In addition, we found VNUT specific inhibitor among the existing drugs, and demonstrated that VNUT inhibitor have the therapeutic effects as well as VNUT knockout mice. In summary, VNUT plays an important roles in onset of neurological and endocrine diseases, and the VNUT inhibitor is a suitable target of drug discovery.
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