The molecular mechanism and physiological significance of vesicular ATP release in purinergic chemical transmission
Project/Area Number |
26460067
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Okayama University |
Principal Investigator |
Miyaji Takaaki 岡山大学, 自然生命科学研究支援センター, 准教授 (40550314)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | プリン作動性化学伝達 / 小胞型ヌクレオチドトランスポーター / ATP / 疼痛 / 炎症 / 神経細胞 / 内分泌細胞 |
Outline of Final Research Achievements |
Vesicular nucleotide transporter (VNUT) is responsible for vesicular storage and release of ATP, and is essential for purinergic chemical transmission. The aim of this research project was to reveal the molecular mechanism of vesicular ATP release and its physiological significance in nervous and endocrine systems. We showed that VNUT knockout mice improve hyperglycemia, insulin resistance, inflammatory and neuropathic pain, and the accompanying inflammation. In addition, we found VNUT specific inhibitor among the existing drugs, and demonstrated that VNUT inhibitor have the therapeutic effects as well as VNUT knockout mice. In summary, VNUT plays an important roles in onset of neurological and endocrine diseases, and the VNUT inhibitor is a suitable target of drug discovery.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase2016
Author(s)
Nakagomi H,Yoshiyama M,Mochizuki T,Miyamoto T,Komatsu R,Imura Y,Morizawa Y,Hiasa M,Kira S,Fujishita K,Shibata K,Shigetomi E,Shinozaki Y,Takeda M,Koizumi S
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 29761-29761
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A polarly localized transporter for efficient manganese uptake in rice.2015
Author(s)
Ueno D., Sasaki A., Yamaji N., Miyaji T., Fujii Y., Takemoto Y., Moriyama S., Che J., Moriyama Y., Iwasaki K., Ma J.F.
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Journal Title
Nature Plants
Volume: 1
Issue: 12
Pages: 15170-15170
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] AtPHT4;4 is a chloroplast-localized ascorbate transporter in Arabidopsis.2015
Author(s)
Miyaji T*, Kuromori T*, Takeuchi Y, Yamaji N, Yokosho K, Shimazawa A, Sugimoto E, Omote H, Ma JF, Shinozaki K, Moriyama Y (* equally contribution)
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 5928-5928
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity2014
Author(s)
Sakamoto S., Miyaji T.,, Hiasa M., Ichikawa R., Iwatsuki K., Shibata A., Uneyama H., Takayanagi R., Yamamoto A., Omote H., Nomura M., Moriyama Y.
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Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 6689-6689
DOI
Related Report
Peer Reviewed / Open Access
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