| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
We showed that CDC14A, a dual-specificity protein phosphatase, was polyubiquitinated by ECS(SPSB1/2/4) E3 ligase complex and degraded by the 26S proteasome. Additionally, we identified Nrf3 as a substrate for ECS(SPSB3). We found that ECS(SPSB3) induces the polyubiquitination of Nrf3 through the binding to the C-terminal region of Nrf3 and negatively regulates the function of Nrf3.
|
