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Involvement of intracellular copper ion homeostasis in epigenetic redox regulation

Research Project

Project/Area Number 26460070
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionGifu Pharmaceutical University

Principal Investigator

Kamiya Tetsuro  岐阜薬科大学, 薬学部, 助教 (60453057)

Co-Investigator(Kenkyū-buntansha) 原 宏和  岐阜薬科大学, 薬学部, 准教授 (30305495)
足立 哲夫  岐阜薬科大学, 薬学部, 教授 (40137063)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsSOD3 / 銅イオン / Atox-1 / エピジェネティクス / gp91phox / EC-SOD / 細胞内銅イオン / NOX2 / ATP7A
Outline of Final Research Achievements

We investigated the involvement of intracellular copper homeostasis in SOD3 regulation during monocytic differentiation into macrophage. We confirmed that the alteration of copper homeostasis after phorbol ester (TPA) treatment regulates SOD3 expression. Moreover, Atox-1, a copper chaperone, functions as a transcription factor of SOD3. It raises the possibility that the alteration of copper homeostasis after TPA treatment changes histone modification, especially in histone acetylation. Overall, our results suggest that intracellular copper ion functions as a key molecule for the redox regulation, and better understanding the role of copper ion might lead to improve vascular diseases.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 8 results,  Open Access: 5 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] University of Illinois at Chicago/University of Bristol/The Ohio State University(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Imperial College of London(英国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Tokyo(Japan)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Ten-eleven translocation 1 functions as a mediator of SOD3 expression in human lung cancer A549 cells2017

    • Author(s)
      Tetsuro Kamiya, Risa Nakahara, Namiki Mori, Hirokazu Hara, Tetsuo Adachi
    • Journal Title

      Free Radical Research

      Volume: 51 Issue: 3 Pages: 329-336

    • DOI

      10.1080/10715762.2017.1313415

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CAPE increases the expression of SOD3 through epigenetics in human retinal endothelial cells2017

    • Author(s)
      Atsuko Ohashi, Hiroyuki Yasuda, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 印刷中

    • NAID

      130006847659

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CoCl<sub>2</sub> Decreases EC-SOD Expression through Histone Deacetylation in COS7 Cells2016

    • Author(s)
      Shuhei Hattori, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 12 Pages: 2036-2041

    • DOI

      10.1248/bpb.b16-00551

    • NAID

      130005171492

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crosstalk mechanism among EMT, ROS, and histone acetylation in phorbol exter-treated human breast cancer MCF-7 cells2016

    • Author(s)
      Tetsuro Kamiya, Aki Goto, Eri Kurokawa, Hirokazu Hara, Tetsuo Adachi
    • Journal Title

      Oxidative Medicine and Cellular Longevity

      Volume: 2016 Issue: 1 Pages: 1284372-1284372

    • DOI

      10.1155/2016/1284372

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Royal jelly constituents increase the expression of extracellular-superoxide disputes through histone acetylation in monocytic THP-1 cells2016

    • Author(s)
      Junya Makino, Rie Ogasawara, Tetsuro Kamiya, Hirokazu Hara, Yukari Mitsugi, Eiji Yamaguchi, Akichika Itoh, Tetsuo Adachi
    • Journal Title

      Journal of Natural Products

      Volume: 79 Issue: 4 Pages: 1137-1143

    • DOI

      10.1021/acs.jnatprod.6b00037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppression of EC-SOD by oxLDL during vascular smooth muscle cell proliferation2016

    • Author(s)
      Junya Makino, Rei Asai, Mao Hashimoto, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: in press Issue: 11 Pages: 2496-2505

    • DOI

      10.1002/jcb.25542

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Caffeic acid phenethyl ester suppresses monocyte adhesion to the endothelium by inhibiting NF-κB/NOX2-derived ROS signaling2016

    • Author(s)
      Risa Nakahara, Junya Makino, Tetsuro Kamiya, Hirokazu Hara, Tetsuo Adachi
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 3 Pages: 174-179

    • DOI

      10.3164/jcbn.15-94

    • NAID

      130005149372

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function2015

    • Author(s)
      Gin-Fu Chen, Varadarajan Sudhahar, Seock-Won Youn, Archita Das, Jaehyung Cho, Tetsuro Kamiya, Norifumi Urao, Ronald D. McKinney, Bayasgalan Surenkhuu, Takao Hamakubo, Hiroko Iwanari, Senlin Li, John W. Christman, Saran Shantikumar, Gianni D. Angelini, Costanza Emanueli, Masuko Ushio-Fukai, Tohru Fukai
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 14780-14780

    • DOI

      10.1038/srep14780

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidized low-density lipoprotein accelerates the destabilization of extracellular-superoxide dismutase mRNA during foam cell formation2015

    • Author(s)
      Makino J, Nii M, Kamiya T, Hara H, Adachi T
    • Journal Title

      Arch. Biochem. Biophys.

      Volume: 575 Pages: 54-60

    • DOI

      10.1016/j.abb.2015.04.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] SOD3発現制御機構としてのクロマチンリモデリングの分子機構2017

    • Author(s)
      神谷哲朗、市原茉莉、原 宏和、足立哲夫
    • Organizer
      日本酸化ストレス学会東海支部 第5回学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Annual Research Report
  • [Presentation] Copper transporter, antioxidant-1 (Atox-1), modulates redox homeostasis during phorbol ester-induced THP-1 cell differentiation2016

    • Author(s)
      Tetsuro Kamiya, Kosuke Takeuchi, Saki Fukudome, Hirokazu Hara, Tetsuo Adachi
    • Organizer
      23rd Annual Meeting of the Society for Redox Biology and Medicine
    • Place of Presentation
      San Fransisco
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SOD3発現制御機構としてのジオキシゲナーゼTET1の関与2016

    • Author(s)
      神谷哲朗、仲原理紗、森 菜美紀、原 宏和、足立哲夫
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] エピジェネティクスを介したSOD3発現制御機構2016

    • Author(s)
      神谷哲朗
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト単球系細胞株におけるSOD3発現制御機構としてのクロマチンリモデリングの解明2016

    • Author(s)
      神谷哲朗、市原茉莉、原 宏和、足立哲夫
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2016-08-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸化ストレスとエピゲノム~『創薬』への展開~2016

    • Author(s)
      神谷哲朗
    • Organizer
      第11回プラズマ医療 サイエンスの扉・サイエンスカフェ
    • Place of Presentation
      名古屋
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Ten-eleven translocation 1 regulates SOD3 expression by its direct binding to human SOD3 promoter region2015

    • Author(s)
      Tetsuro Kamiya, Risa Nakahara, HIrokazu Hara, Tetsuo Adachi
    • Organizer
      22nd Annual Meeting of the Society for Free Radical Biology and Medicine
    • Place of Presentation
      Boston
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ten-eleven translocation 1を介したEC-SOD遺伝子のDNA脱メチル化機構2015

    • Author(s)
      神谷哲朗、仲原理沙、原 宏和、足立哲夫
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] THP-1細胞分化時のEC-SOD発現制御機構における細胞内銅イオンの役割2015

    • Author(s)
      神谷 哲朗、竹内 康佑、原 宏和、足立 哲夫
    • Organizer
      日本酸化ストレス学会東海支部 第3回学術集会
    • Place of Presentation
      名城大学八事キャンパス(愛知)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Crosstalk among ROS, epigenetic and TPA-induced EMT in human breast cancer MCF7 cells.2014

    • Author(s)
      Tetsuro Kamiya, Aki Goto, Hirokazu Hara, Tetsuo Adachi
    • Organizer
      21st Annual Meeting of the Society for Free radical Biology and Medicine
    • Place of Presentation
      Sheraton Seattle, Seattle, WA
    • Year and Date
      2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] レドックス制御機構としてのエピジェネティクス2014

    • Author(s)
      神谷 哲朗
    • Organizer
      第26回腎とフリーラジカル
    • Place of Presentation
      愛知県産業労働センター ウインクあいち(愛知)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 腎と透析2016

    • Author(s)
      神谷哲朗、安田浩之、原 宏和、山田晴生、足立哲夫
    • Total Pages
      161
    • Publisher
      東京医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 腎とフリーラジカル 第12集2014

    • Author(s)
      神谷 哲朗、服部 脩平、原 宏和、足立 哲夫
    • Total Pages
      130
    • Publisher
      東京医学社
    • Related Report
      2014 Research-status Report
  • [Remarks] 岐阜薬科大学 医療薬剤学大講座 臨床薬剤学研究室

    • URL

      http://sv1.gifu-pu.ac.jp/lab/rinyaku/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] 岐阜薬科大学 医療薬剤学大講座 臨床薬剤学研究室

    • URL

      http://www.gifu-pu.ac.jp/lab/rinyaku/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-02-03  

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