Identifying the novel therapeutic targets by investigating the regulatory mechanism of transcription complex during the development of heart failure
| Project/Area Number |
26460071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋細胞肥大 / 心不全 / ＧＡＴＡ４ / ｐ３００ / GATA4 / p300 / 新規細胞肥大 |
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| Outline of Final Research Achievements |
GATA4 forms a large complex with an intrinsic histone acetyltransferase, p300 and these factors are involved in transcriptional regulation during myocardial cell hypertrophy. Moreover, noble p300/GATA4 binding partners, PRMT5/MEP5 complex, SWI/SNF complex, NuRD complex, and N-CoR/SMRT complex form a functional complex with p300/GATA4 and suppress hypertrophic responses in cardiomyocytes and development of heart failure.
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Report
(4 results)
Research Products
(117 results)
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[Journal Article] Optimal Dose-Setting Study of Curcumin for Improvement of Left Ventricular Systolic Function After Myocardial Infarction in Rats2014
Author(s)
Sunagawa y, Sono S, Katanasaka Y, Funamoto M, Hirano S, Miyazaki Y, Hojo Y,Suzuki H, Morimoto E, Marui A, Sataka R, Ueno M, Wada H, Hasegawa K, Morimoto t
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 4
Pages: 329-336
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Heart-specific PRMT5 overexpression promotes cardiac hypertrophy in mice2014
Author(s)
Yusuke Miyazaki, Yasufumi Katanasaka, Ryoga Sakurai, Hiroki Wakabayashi, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Tatsuya Morimoto, Hidetoshi Suzuki, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Tatsuya Morimoto
Organizer
第19回静岡健康・長寿学術フォーラム
Place of Presentation
静岡
Year and Date
2014-11-07
Related Report
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[Presentation] WDR5, a novel GATA4-binding protein, suppresses p300/GATA4-dependent gene transcription2014
Author(s)
Nana Amano, Yasufumi Katanasaka, Yosuke Nagai, Yoichi Sunagawa, Hidetoshi Suzuki, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Tatsuya Morimoto
Organizer
第19回静岡健康・長寿学術フォーラム
Place of Presentation
静岡
Year and Date
2014-11-07
Related Report
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[Presentation] Methylosome protein 50 promoted the association of Protein arginine methyltransferase 5 with p3002014
Author(s)
Yusuke Miyazaki, Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Junya Nakada, Hidetoshi Suzuki, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Tatsuya Morimoto
Organizer
World Congress of Cardiology Scientific Sessions 2014
Place of Presentation
Melboume, Australia
Year and Date
2014-05-05
Related Report
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[Presentation] MEK-1-dependent Phosphorylation of GATA4 Attenuates the Repressor Function of Novel GATA4 Binding Proteins, RbAp48/46, during Cardiomyocyte Hypertrophy2014
Author(s)
Yoichi Sunagawa, Yasufumi Katanasaka, Hidetoshi Suzuki, Naruto Hajika, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
Organizer
第18回国際心血管生物学会
Place of Presentation
京都
Year and Date
2014-04-14 – 2014-04-17
Related Report
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