Mechanisms of remodeling of white adipocytes to brown-like adipocytes (browning) in human mesenchymal stem cells.
Project/Area Number |
26460077
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Kinjo Gakuin University (2016) Showa University (2014-2015) |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 脂質代謝 / 脂肪滴 / 脂肪細胞 |
Outline of Final Research Achievements |
Appearance of brown-like adipocytes within white adipose tissue depots (browning) is supposed to be a new target in anti-obesity therapy. The aim of this study was to assess the browning effect of various compounds such as fatty acids, polyphenols, FGF21 and irisin in human adipose-derived mesenchymal stem cells (hADSC). I found that irisin and FGF21 enhanced expression of BAT marker UCP1 and decreased levels of a lipid droplet-associated protein, perilipin1. In further, FGF21 induced levels of perilipin2, suggesting the remodeling from large lipid droplets to smaller droplets.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Tomohiro Yamaguchi, Noriyuki Fujikawa, Satomi Nimura, Yutaro Tokuoka, Sonoka Tsuda, Toshihiro Aiuchi, Rina Kato, Takashi Obama, Hiroyuki Itabe. Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation.2015
Author(s)
Yamaguchi T, Fujikawa N, Nimura S, Tokuoka Y, Tsuda S, Aiuchi T, Kato R, Obama T, Itabe H.
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Journal Title
BBA - Molecular and Cell Biology of Lipids
Volume: 1851
Issue: 10
Pages: 1285-1295
DOI
Related Report
Peer Reviewed
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