Elucidation of structure and physiological function of the cytochrome c-LRG complex
| Project/Area Number |
26460082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
Inoue Seiji 大阪薬科大学, 薬学部, 教授(移行) (70183184)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生体分子 / 蛋白質 / 生理活性 |
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| Outline of Final Research Achievements |
Leucine-rich alpha2-glycoprotein (LRG), one of the serum proteins with unknown function, bind tightly and specifically to autologous cytochrome c (Cyt c). In the present study, LRG was found to bind to Cyt c in the manner that inhibit the electron transport activity of Cyt c. In the pathogenesis of diseases with organ dysfunction, the Cyt c-LRG complex appeared in the blood and the complex was suggested to be involved in the G-CSF expression.
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Report
(4 results)
Research Products
(3 results)
