| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have examined a possibility that an activity and expression of tyrosinase, a copper binding proteina and key enzyme of melanin synthesis, is regulated by an intracellular level of copper ion. We found that RNF152, an ubiquitin ligase, specifically interacts with and ubiquitinates tyrosinase. Since RNF152 dose not interacts with and ubiquitinates other melanin synthesis enzyme, Tyrp-1, we concluded that RNF152 may be involved in the regulation of melanin synthesis by controlling an expression level and intracellular localization of tyrosinase in melanocytes. We are unable to show the data that copper-transporters regulate an expression level and intracellular localization of tyrosinase in melanocytes.
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