| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It has been unclear whether nucleoporin Nup88 overexpressing in tumor tissues promotes cancer malignancy such as cell motility. In this study, we characterized a novel interaction between Nup88 and vimentin intermediate filament protein and examined its involvement in cell motility. Nup88, but not other nucleoporins we tested, bound to vimentin specifically. In addition, Nup88 interacted with vimentin directly. The N-terminal 541 amino acid residues of Nup88 bound to the N-terminal 96 amino acid residues of vimentin molecule. This interaction affected the vimentin organization process. Nup88 overexpressed in cells promoted cell motility in the presence of vimentin. Nup88, thus, may contribute to cell motility through changing the organization of vimentin.
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