Regulatory mechanism of inflammation and mitochondrial function by galactolipids and SM
| Project/Area Number |
26460093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Atsushi 千葉大学, 大学院薬学研究院, 教授 (80130029)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | スフィンゴ脂質 / セラミド / 大腸炎モデルマウス / カルジオリピン / ミトコンドリア / ラクトシルセラミド / ホスホリパーゼA2 / セラミドキナーゼ / セラミド-1-リン酸 / 大腸炎 / セラミド－１－リン酸 / スフィンゴミエリン / ガラクト脂質 / アラキドン酸 |
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| Outline of Final Research Achievements |
Sphingolipids are components of cellular membranes and also act as extra- and intra-cellular signals. In the present study, I examined following problems such as roles of sphingolipids on alpha-cytosolic phospholipase A2 (cPLA2alpha) that regulates inflammatory responses, regulatory mechanisms of ceramide kinase (CerK), and roles of galactose-containing sphingolipids on these enzymes. I showed that 1) caldiolipin that mainly localizes in the mitochondria bind with and activates ceramide kinase directly, 2) a galactose-containing lipid, lactosylceramide, activated cPLA2alpha via NADPH oxidase-mediated formation of reactive oxygen species, 3) progression of experimental colitis was enhanced in CerK-knockout mice.
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Report
(4 results)
Research Products
(24 results)
