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The role of basophils and coagulation reactions for pathology of chronic spontaneous urticaria

Research Project

Project/Area Number 26460097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionHiroshima University

Principal Investigator

Yanase Yuhki  広島大学, 医歯薬保健学研究院(医), 助教 (40452586)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords慢性蕁麻疹 / 組織因子 / 好塩基球 / 血管内皮細胞 / 血管透過性亢進 / ヒスタミン / LPS / 血液凝固 / 単球 / 肥満細胞 / Tissue Factor (TF)
Outline of Final Research Achievements

Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily recurring wheal and flare with itch in association with mast cell degranulation. Although the involvement of the blood coagulation cascade and infections in CSU has been suggested, the trigger of the coagulation cascade and the relationship of infections to wheal formation induced by mast cell degranulation are unclear. We here investigated the effect of histamine and LPS on tissue factor (TF) expression on endothelial cells followed by activation of the coagulation pathway and intercellular gap formation. Histamine released from basophils and LPS synergistically induced TF expression on human endothelial cells (HUVEC) via the histamine H1 receptor and TLR-4. Moreover, the synergistically expressed TF on HUVECs induced contraction and intercellular gaps between HUVECs in the presence of plasma. These reactions were inhibited by an antagonist against protease activated receptor (PAR)-1.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] Synergistic expression of tissue factor on vascular endothelial cells by histamine and LPS triggers the extrinsic coagulation pathway followed by vascular hyperpermeability2017

    • Author(s)
      Yuhki Yanase, Satoshi Morioke, Kazumasa Iwamoto, Takaaki Hiragun, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Michihiro Hide
    • Organizer
      The 19th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      大阪
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vitro リアルタイム血管透過性評価法の開発2016

    • Author(s)
      柳瀬雄輝、入福令子、川口智子、内田一恵、秀道広
    • Organizer
      第20回日本ヒスタミン学会
    • Place of Presentation
      倉敷市
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] インピーダンスセンサを利用した無標識・リアルタイム血管透過性評価法の開発2016

    • Author(s)
      柳瀬雄輝、川口智子、宇野重康、秀道広
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      新潟市
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 血管内皮細胞と血管内皮細胞由来マイクロパーティクルの組織因子発現に対するLPSとヒスタミンの影響2016

    • Author(s)
      柳瀬雄輝、中谷絵理子、厚味厳一、内田一恵、秀 道広
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮細胞の組織因子発現に対する感染とヒスタミンの影響2016

    • Author(s)
      柳瀬雄輝、森桶聡、岩本和真、平郡隆明、内田一恵、秀道広
    • Organizer
      第129回日本薬理学会近畿部会
    • Place of Presentation
      広島市
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性蕁麻疹の病態と外因系血液凝固反応の関係解明2016

    • Author(s)
      柳瀬雄輝、内田一恵、川口智子、秀道広
    • Organizer
      第17回Parmaco-Hematologyシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性蕁麻疹の病態における血液凝固反応の役割とオロパタジンの影響2015

    • Author(s)
      柳瀬雄輝
    • Organizer
      第66回広島県皮膚科講習会
    • Place of Presentation
      広島
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 慢性蕁麻疹病態と血液凝固反応の関係解明2015

    • Author(s)
      柳瀬雄輝、森桶 聡、岩本和真、平郡隆明、内田一恵、秀 道広
    • Organizer
      第16回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-06-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮細胞の組織因子発現に対するヒスタミンの影響2015

    • Author(s)
      柳瀬雄輝、森桶 聡、岩本和真、平郡隆明、内田 一恵、秀 道広
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮細胞の組織因子発現に対するヒスタミンの影響2014

    • Author(s)
      柳瀬雄輝、森桶 聡、岩本和真、平郡隆明、内田 一恵、秀 道広
    • Organizer
      日本ヒスタミン学会
    • Place of Presentation
      尼崎市
    • Year and Date
      2014-10-10 – 2014-10-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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